Do quinolones cause tendon rupture?

Approximately 2% to 6% of all Achilles tendon ruptures in people older than 60 years can be attributed to quinolones. Conclusions Current exposure to quinolones increased the risk of Achilles tendon rupture. The risk is highest among elderly patients who were concomitantly treated with corticosteroids.

Do quinolones cause tendon rupture?

Approximately 2% to 6% of all Achilles tendon ruptures in people older than 60 years can be attributed to quinolones. Conclusions Current exposure to quinolones increased the risk of Achilles tendon rupture. The risk is highest among elderly patients who were concomitantly treated with corticosteroids.

Do all quinolones cause tendonitis?

“In our study, fluoroquinolones as a class were not associated with the increased risk of tendon ruptures,” the researchers point out. “Neither ciprofloxacin nor moxifloxacin exhibited any risk for tendon ruptures. Levofloxacin did exhibit significant increased risk.

How do fluoroquinolones affect tendons?

One well-described and serious adverse event associated with fluoroquinolones is tendinitis and tendon rupture. These injuries can result in long-term sequelae, including chronic pain and mobility restrictions, and may warrant surgical intervention.

Can fluoroquinolones cause tendonitis?

Tendinitis preceded rupture in 50% of 42 cases. Compared with the use of other antibiotics, the use of fluoroquinolones carries a 3.8-fold increased risk of Achilles tendinopathy.

Is tendon damage from Levaquin permanent?

Fluoroquinolone medicines (which contain ciprofloxacin, levofloxacin, lomefloxacin, moxifloxacin, norfloxacin, ofloxacin, pefloxacin, prulifloxacin and rufloxacin) can cause long-lasting, disabling and potentially permanent side effects involving tendons, muscles, joints and the nervous system.

What medications affect tendons?

Drug-induced tendinopathy, including tendinitis and tendon rupture, is most frequently associated with aromatase inhibitors, fluoroquinolones, glucocorticoids, and statins.

What drugs affect the Achilles tendon?

Two major categories of drugs used in Achilles tendon rupture and Achilles tendinosis are analgesics (opioid and nonopioid) and nonsteroidal anti-inflammatory agents (NSAIDs).

How common are tendon problems with Levaquin?

Achilles tendinopathy and tendon rupture are adverse side effects of levofloxacin treatment well recognised in the literature, but its presentation is very uncommon. The incidence rate for tendinopathy is 0.1% to 0.01%, and the incidence rate for tendon rupture is less than 0.01%.

How common are tendon problems with levofloxacin?

What can weaken tendons?

With repetitive or prolonged activities, forceful exertion, awkward and static postures, vibration, and localized mechanical stress, the tendons fibers can tear apart in much the same way a rope becomes frayed.

Can quinolones cause tendinitis?

Quinolones – A Tendoncy to Rupture. Tendon rupture and tendinitis are rare adverse events associated with the use of quinolone antibiotics. The Achilles tendon is most frequently involved but other sites can also be affected.

Can quinolone antibiotics cause Achilles tendon rupture?

Tendon rupture and tendinitis are rare adverse events associated with the use of quinolone antibiotics. The Achilles tendon is most frequently involved but other sites can also be affected 1 .

Does fluoroquinolone cause tendon rupture?

Relative and Absolute Risk of Tendon Rupture with Fluoroquinolone and Concomitant Fluoroquinolone/Corticosteroid Therapy: Population-Based Nested Case-Control Study Risk of tendon rupture with fluoroquinolones depends on timing, cumulative dose and concomitant exposure to oral corticosteroids.

What are the side effects of quinolone antibiotics?

Tendon rupture and tendinitis are rare adverse events associated with the use of quinolone antibiotics. The Achilles tendon is most frequently involved but other sites can also be affected.