What does ABCG5 do?
The ABCG5 gene provides instructions for making sterolin-1, which makes up half of a protein called sterolin. The other half of the sterolin protein, sterolin-2, is produced from a gene called ABCG8.
Which disease or disorder results from deficiency of ABCG5 and ABCG 8?
The strongest evidence that ABCG5 and ABCG8 act as obligate heterodimers is obtained from genetic data: sitosterolemia, a disease resulting from a deficiency of functional sterol transport, is caused by mutations in both alleles of either ABCG5 or ABCG8 that nonetheless lead to indistinguishable phenotypes.
What is the role of ABCA1?
Physiological role ABCA1 mediates the efflux of cholesterol and phospholipids to lipid-poor apolipoproteins (apoA1 and apoE) (reverse cholesterol transport), which then form nascent high-density lipoproteins (HDL). It also mediates the transport of lipids between Golgi and cell membrane.
What is ABCA1 cellular function?
The ABCA1 gene belongs to a group of genes called the ATP-binding cassette family, which provides instructions for making proteins that transport molecules across cell membranes. The ABCA1 protein is produced in many tissues, with high amounts found in the liver and in immune system cells called macrophages.
What is nascent HDL?
Nascent HDL (High-Density Lipoprotein) Discs Carry Cholesterol to HDL Spheres. Effects of HDL Particle Remodeling on Cholesterol Efflux. Alexei V.
What is ALDP?
The adrenoleukodystrophy protein (ALDP) helps your body break down very long chain fatty acids (VLCFAs).
What does VLDL stand for?
Very-low-density lipoprotein (VLDL) cholesterol is produced in the liver and released into the bloodstream to supply body tissues with a type of fat (triglycerides).
What are the differences between LDL and HDL?
As a general rule, HDL is considered “good” cholesterol, while LDL is considered “bad.” This is because HDL carries cholesterol to your liver, where it can be removed from your bloodstream before it builds up in your arteries. LDL, on the other hand, takes cholesterol directly to your arteries.
What is the function of ABCG5 and ABCG8?
ATP-binding cassette (ABC) transporters G5 (ABCG5) and G8 (ABCG8) form an obligate heterodimer that limits intestinal absorption and facilitates biliary secretion of cholesterol and phytosterols. Consistent with their function, ABCG5 and ABCG8 are located on the apical membrane of enterocytes and hepatocytes.
Are ABCG5/G8 transporters linked to hypercholesterolemia?
Polymorphisms in ABCG5/G8 Transporters Linked to Hypercholesterolemia and Gallstone Disease ATP-binding cassette (ABC) transporters function in the homeostasis of lipids. Dysfunction of ABC transporters is frequently associated with disease.
Are ABCG5 and ABCG8 obligate dimers?
Two proteins, ABCG5 and ABCG8, encoded by the sitosterolemia locus, work as obligate dimer … ABCG5 and ABCG8: more than a defense against xenosterols J Lipid Res. 2018 Jul;59(7):1103-1113.doi: 10.1194/jlr.R084244. Epub 2018 May 4. Authors
Are ABC G5 and ABCG8 polymorphisms associated with hypercholesterolemia and gallstone disease risk?
This review examines links between polymorphisms of ABC G5 (ABCG5) and G8 (ABCG8) transporter genes to hypercholesterolemia and to gallstone disease risk.