What does high Antiscleroderma 70 antibodies mean?

Test Details Scl-70 may identify a subset of scleroderma patients with severe skin, joint, and lung disease. In addition, the presence of Scl-70 in Raynaud phenomenon may indicate a poor prognosis.

Does everyone have Scl 70 antibodies?

Anti-Scl-70 antibodies are found in about 40% of patients with diffuse cutaneous systemic sclerosis (dcSSc) and less than 10% of patients with limited cutaneous systemic sclerosis (lcSSc) [35, 36]. The frequency of anti-Scl-70 antibodies in SSc with pulmonary fibrosis is about 45% [35].

What is considered a positive Scl 70?

<1.0 U (negative) > or =1.0 U (positive) Reference values apply to all ages. A positive test result for Scl 70 antibodies is consistent with a diagnosis of scleroderma.

Can you have scleroderma with a negative Scl 70?

Systemic Scleroderma Patients with early diffuse cutaneous scleroderma frequently have delayed Raynaud’s, acute onset, many constitutional symptoms, arthralgias, tendon friction rubs, swollen puffy hands, and early diffuse skin thickening. They may have anti–Scl-70 antibody, as well as anti–RNA polymerase III.

Can you have a positive Scl 70 and not have scleroderma?

Serum anti-topoisomerase, also known as SCL-70, is specific to diffuse scleroderma (and the test is positive in 20% of people with scleroderma). Two-thirds of patients with this antibody have diffuse scleroderma.

What is the prevalence of Scl-70 antibody in scleroderma?

0.5 mL ( Note: This volume does not allow for repeat testing.) Scl-70 antibody is seen in 20% of patients with scleroderma, and in some patients with CREST syndrome (calcinosis, Raynaud, esophageal dysfunction, sclerodactyly, telangiectasia).

What is the difference between Scl-70 and anti-centromere antibodies?

  The presence of anti-SCL-70 (anti-topoisomerase) antibodies is highly specific to the diagnosis of diffuse scleroderma, while the presence of anti-centromere antibodies is highly specific to the diagnosis of limited scleroderma.

Which antibodies are used in the workup of systemic scleroderma?

As indicated in Table 2 below, the three most common antibodies found in patients with systemic scleroderma are Scl-70, centromere, and RNA Polymerase III.

What are speckled pattern immunofluorescent antinuclear antibody (Scl-70) tests?

These syndromes are also associated with a high frequency of speckled pattern immunofluorescent antinuclear antibody tests. Scl-70 may identify a subset of scleroderma patients with severe skin, joint, and lung disease.