What is a long-acting dihydropyridine calcium channel blocker?
Dihydropyridine calcium channel blockers are drugs used to treat high blood pressure and severe angina (chest pain caused by lack of oxygen to the heart muscle). Dihydropyridines are one of the different types of calcium channel blockers; they predominately act on blood vessels with less effect on the heart.
Which are the examples of dihydropyridines?
Examples of dihydropyridines include:
- amlodipine (Norvasc)
- felodipine (Plendil)
- isradipine (DynaCirc)
- nicardipine (Cardene)
- nifedipine (Adalat, Procardia)
- nimodipine (Nimotop, Nymalize)
- nisoldipine (Sular)
Is amlodipine a long-acting dihydropyridine?
Effects of amlodipine, a long-acting dihydropyridine calcium antagonist in aging hypertension: pharmacodynamics in relation to disposition. Clin Pharmacol Ther.
Is amlodipine short or long-acting?
Amlodipine, a long-acting calcium channel blocker, attenuates morning blood pressure rise in hypertensive patients.
Is verapamil a non dihydropyridine?
A calcium channel blocker used to treat hypertension and to manage chronic stable angina. A non-dihydropyridine calcium channel blocker used in the treatment of angina, arrhythmia, and hypertension….Calcium Channel Blockers (Nondihydropyridine)
| Drug | Target | Type |
|---|---|---|
| Verapamil | P-glycoprotein 1 | transporter |
| Verapamil | Solute carrier family 22 member 1 | transporter |
Is diltiazem a dihydropyridine?
Diltiazem is a non-dihydropyridine calcium channel blocker(CCB). Therapeutic effects occur through various mechanisms. Primarily, diltiazem inhibits the inflow of calcium ions into the cardiac, smooth muscle during depolarization.
Is nifedipine a dihydropyridine?
Dihydropyridines — The dihydropyridines, including nifedipine, isradipine, felodipine, nicardipine, nisoldipine, lacidipine, amlodipine, and levamlodipine are potent vasodilators that have little or no negative effect clinically upon cardiac contractility or conduction.
Is verapamil more Cardioselective than diltiazem?
The more cardioselective CCBs (verapamil and diltiazem) decrease heart rate and contractility, which leads to a reduction in myocardial oxygen demand, which makes them excellent antianginal drugs.
What is the difference between dihydropyridine and Nondihydropyridine?
Dihydropyridine (DHP) CCBs tend to be more potent vasodilators than non-dihydropyridine (non-DHP) agents, whereas the latter have more marked negative inotropic effects.
Is Lacidipine a dihydropyridine?
Lacidipine (Caldine, Lacimen, Lacipil, Midotens, Motens) is a once-daily, orally-administered, lipophilic dihydropyridine calcium antagonist with an intrinsically slow onset of activity, resulting in a lack of reflex tachycardia.
What is a long acting dihydropyridine blocker?
A long-acting dihydropyridine calcium channel blocker. It is effective in the treatment of ANGINA PECTORIS and HYPERTENSION. A synthetic dihydropyridine and a calcium channel blocker with antihypertensive and antianginal properties.
What is dihydropyridine used to treat?
1,4 dihydropyridine; centrally acting calcium channel blocker used in the treatment of a wide range of disorders, including drug withdrawal, AIDS motor/cognitive disorder, and post cardiac surgery recovery.
Are dihydropyridines safe for angina patients?
Long-acting dihydropyridines (e.g., extended release nifedipine, amlodipine) have been shown to be safer anti-hypertensive drugs, in part, because of reduced reflex responses. This characteristic also makes them more suitable for angina than short-acting dihydropyridines.
What are the possible adverse effects of dihydropyridine calcium channel blockers?
Dihydropyridine calcium channel blockers often cause adverse effects that necessitate withdrawal, particularly in more fragile patients, such as those with renal dysfunction.