What is CD68 a marker for?

CD68 is broadly used as cancer-associated diagnostic and prognostic marker. It is used to identify neoplasms with macrophage lineage and also may be expressed by tumor cells from other lineages.

What is CD68 stain?

CD68 (Kp-1) is a glycoprotein used as a monocyte/macrophage marker but is relatively non-specific. It also can stain myeloid cells, dendritic cells, fibroblasts, Langerhans cells and others. CD163 is a member of the scavenger receptor family and is specific for the monocyte/macrophage lineage [9, 10].

Do mice express CD68?

CD68 is expressed by macrophages and osteoclasts. (A) CD68 and β-actin expression in mouse bone marrow suspension cells treated with 44 ng/mL M-CSF +/− 100 ng/mL RANKL for indicated days (d). M-CSF increases expression of CD68 in a time dependant manner, and RANKL ligand induces an accelerated gel migration rate.

What cells are CD68 positive?

CD68 is a sialomucin and a member of the scavenger receptor supergene family [5, 108]. This molecule is expressed by monocytes and macrophages as well as subsets of CD34-positive hematopoietic stem cells, dendritic cells, neutrophils, basophils, and mast cells [5, 109, 110].

What are CD68 cells?

CD68 (Cluster of Differentiation 68) is a protein highly expressed by cells in the monocyte lineage (e.g., monocytic phagocytes, osteoclasts), by circulating macrophages, and by tissue macrophages (e.g., Kupffer cells, microglia).

Is CD68 intracellular or extracellular?

MS and CD68 are closely related to the family of lysosomal-associated membrane proteins (lamps) (25). They are predominantly intracellular proteins, found mainly in the late endosomal compartment (22, 26, 27).

What are CD68 macrophages?

Do monocytes express CD68?

CD68 can be expressed by macrophage/monocytes (including Kupffer cells and microglia), basophils, dendritic cells, fibroblasts (Verh Dtsch Ges Pathol 2003;87:215, Ann Rheum Dis 2004;63:774), Langerhans cells, mast cells, myeloid cells, CD34+ progenitor cells, neutrophils, osteoclasts, activated platelets and B and T …

Is CD68 a mouse macrophage marker?

Anti-Mouse CD68 clone FA-11 (MCA1957) has been widely used as a marker for mouse macrophages. Studies have shown that the antigen (Macrosialin) recognized by the anti-mouse CD68 antibody is the mouse homologue of human CD68. Murine CD68 is expressed on macrophages and also on myeloid derived osteoclasts.