What is the APOA2 gene?
APOA2 Gene – Apolipoprotein A2 This gene encodes apolipoprotein (apo-) A-II, which is the second most abundant protein of the high density lipoprotein particles. The protein is found in plasma as a monomer, homodimer, or heterodimer with apolipoprotein D.
What does apolipoprotein B do?
Apolipoprotein B-100 is a protein that helps carry fat and cholesterol through your body. It is also called apolipoprotein B or apoB, for short. Your body needs fat and cholesterol to produce hormones and keep your cells healthy. Despite being necessary, fat and cholesterol don’t dissolve well in the blood.
What does APO A2 do?
Function. APOA2 encodes apolipoprotein A-II, (ApoA-II) which is the second most abundant protein of the high density lipoprotein particles. The protein is found in plasma as a monomer, homodimer, or heterodimer with apolipoprotein D.
What is apolipoprotein A1 and B test?
Apolipoprotein A-1 (Apo A-1) and apolipoprotein B (Apo B) are used alongside other routine lipid tests to help determine an individual’s risk of developing CVD – not as a general population screen but rather where patients have a family history of heart disease &/or hyperlipidaemia to help determine the cause ( …
What is the difference between apo b100 and apo b48?
Apolipoprotein B-48 ApoB-48 is synthesized only by the intestine in humans, while apoB-100 is synthesized primarily by the liver. Therefore, apoB-48 is a most appropriate biomarker for cardiovascular and nutritional investigation of postprandial chylomicron metabolism.
What is a good apolipoprotein B level?
The normal range for apolipoprotein B is generally below 120 mg/dL (milligrams per deciliter), or 1.2 g/L (grams per liter), and optimally below 90 mg/dL (0.9 g/L). Ranges may vary slightly between laboratories.
What is normal ApoB level?
Normal levels of ApoB-100 in adults are less than 100 mg/dL. Your risk is high if you have a result greater than 110 mg/dL. High levels of ApoB may mean that you have a higher than normal risk of developing cardiovascular disease. An ApoA test (linked with “good” cholesterol) may also be done with the ApoB test.
What happens when lipoprotein is high?
What do the results mean? A high lipoprotein (a) level may mean you are at risk for heart disease. There are no specific treatments to lower lipoprotein (a). Your level of lipoprotein (a) is determined by your genes and is not affected by your lifestyle or by most medicines.
What does the APOA2 gene code for?
The APOA2 gene (OMIM 107670) encodes the apolipoprotein A-II lipoprotein (ApoAII), a major constituent of HDL that is mainly produced in the liver and small intestine. About 10–15% of American adults [128] carry the variant −265T>C (rs5082), which is located in the promoter region of the APOA2 gene and reduces ApoAII protein production.
What is apolipoprotein A-II (APOA2)?
Get a custom nutrition plan. Apolipoprotein A-II (APOA2) is an important protein involved in the transport of lipids throughout the blood, and is encoded for by the APOA2 gene 1. APOA2 is the second most abundant of the HDL particles and therefore plays a key role in regulating HDL levels and overall cholesterol metabolism.
Is APOA2 produced by the intestine or liver?
Inasmuch as APOA2 is believed to be produced exclusively by the liver, these data suggest a dominant role of the liver vs. the intestine in mediating the effect of PPARα activation.
Is guacamole or chocolate better for APOA2?
Consider two groups of people with the APOA2 genotype −265C/C (two copies of the C allele). The people in one group regularly choose the extra chocolate bar, while those in the other group instead opt for a snack of guacamole with the same amounts of calories and fat.