What are CD68+ cells?

CD68 (Cluster of Differentiation 68) is a protein highly expressed by cells in the monocyte lineage (e.g., monocytic phagocytes, osteoclasts), by circulating macrophages, and by tissue macrophages (e.g., Kupffer cells, microglia).

What is CD68 antibody?

CD68, also known as Gp110 or macrosialin, is a type I transmembrane glycoprotein of 110kDa. Pulford et al used the six antibodies discussed previously to evaluate expression of this protein in human blood, tissue and cell lines, and demonstrated that all six antibodies stained macrophages and monocytes.

What is the function of CD68?

CD68 is broadly used as cancer-associated diagnostic and prognostic marker. It is used to identify neoplasms with macrophage lineage and also may be expressed by tumor cells from other lineages.

What does CD68 positive mean?

Increased numbers of CD68-positive tumor macrophages indicate an adverse overall outcome in Hodgkin lymphoma. Significant co-localization of CD36 receptor with cells of the macrophage lineage, such as CD68 positive cells.

Do human monocytes express CD68?

CD68 is a sialomucin and a member of the scavenger receptor supergene family [5, 108]. This molecule is expressed by monocytes and macrophages as well as subsets of CD34-positive hematopoietic stem cells, dendritic cells, neutrophils, basophils, and mast cells [5, 109, 110].

Is CD4 and lymphocyte same?

A type of lymphocyte. CD4 T lymphocytes (CD4 cells) help coordinate the immune response by stimulating other immune cells, such as macrophages, B lymphocytes (B cells), and CD8 T lymphocytes (CD8 cells), to fight infection. HIV weakens the immune system by destroying CD4 cells.

What is the function of CD4?

Function. CD4 is a co-receptor of the T cell receptor (TCR) and assists the latter in communicating with antigen-presenting cells. The TCR complex and CD4 bind to distinct regions of the antigen-presenting MHC class II molecule.

What is Macrilen™?

Macimorelin (Macrilen™) was invented and first synthesized by the research group of Professor Martinez at University of Montpellier, Centre National de la Recherche Scientitifique ( CNRS ), France. This transpired from a long-lasting research collaboration with Aeterna Zentaris.

What is Macimorelin (aezs-130)?

“Macimorelin (AEZS-130)-stimulated growth hormone (GH) test: validation of a novel oral stimulation test for the diagnosis of adult GH deficiency”. The Journal of Clinical Endocrinology and Metabolism. 98 (6): 2422–9. doi: 10.1210/jc.2013-1157.

What is Macimorelin acetate?

Macimorelin acetate is described chemically as D-Tryptophanamide, 2-methylalanyl-N- [ (1R)-1- (formylamino)-2- (1H-indol-3-yl)ethyl]-acetate. Macimorelin (Macrilen™) was invented and first synthesized by the research group of Professor Martinez at University of Montpellier, Centre National de la Recherche Scientitifique ( CNRS ), France.