Is DKK3 a tumor suppressor?

Description… DKK3, a member of the dickkopf family, is a secreted protein containing two cysteine rich regions and involved in embryonic development through its interactions with the Wnt signaling pathway. The expression of the DKK3 gene is decreased in a variety of cancer cell lines and it may function as a tumor suppressor gene.

What is the biological role of the DKK3 gene?

DKK3 is a divergent member of the DKK protein family. Evidence suggests that DKK3 may serve as a potential therapeutic target in several types of human cancers. We review here the biological role of DKK3 as a tumor suppressor gene (TSG) or oncogene, and its correlation with various miRNAs.

What is dickkopf-3 (DKK3)?

Dickkopf-3 (DKK3), also known as REIC, is a secreted glycoprotein. DKK3 is aberrantly expressed in various types of human malignant tumours.

What is the difference between DKK1 DKK2 and DKK3?

DKK family members (DKK1, 2, and 4) bind to LRP5/6 and Kremen, and inhibit Wnt/β-catenin signaling by sequestration of Wnt receptors. DKK3 does not bind to LRP5/6; instead, its cytoplasmic isoform, DKK3b, inhibits the nuclear translocation of β-catenin.