What class of medication is eptifibatide?

Eptifibatide is a glycoprotein IIb/IIIa class platelet inhibitor drug used to reduce ischemic cardiac events in specific patient populations. This activity outlines the indications, mechanism of action, administration, adverse effects, contraindications, monitoring, and toxicity of eptifibatide.

Does ticagrelor reduce platelets?

A P2Y12 receptor antagonist, ticagrelor, is unique among antiplatelet drugs, because ticagrelor inhibits the platelet P2Y12 receptor in a reversible manner, and because it demonstrates a wide palette of advantageous pleiotropic effects associated with the increased concentration of adenosine.

What ticagrelor is used for?

Descriptions. Ticagrelor is used alone or together with aspirin to lessen the chance of heart attack or stroke in patients with acute coronary syndrome (ACS) or a history of heart attack. Acute coronary syndrome is a condition where the blood flow to the heart is blocked.

What is the purpose of Abciximab?

Abciximab is used to lessen the chance of heart attack in people who need percutaneous coronary intervention (PCI), a procedure to open blocked arteries of the heart.

Is Integrilin a blood thinner?

BRAND NAME(S): Integrilin. USES: Eptifibatide is a type of “blood thinner” used to prevent blood clots that can cause a heart attack or other serious blood flow problems.

How does eptifibatide work?

Mechanism of action Eptifibatide inhibits platelet aggregation by reversibly binding to the platelet receptor glycoprotein (GP) IIb/IIIa of human platelets, thus preventing the binding of fibrinogen, von Willebrand factor, and other adhesive ligands. Inhibition of platelet aggregation occurs in a dose- and concentration-dependent manner.

What is the nonimmunogenicity of eptifibatide?

Nonimmunogenicity of eptifibatide, a cyclic heptapeptide inhibitor of platelet glycoprotein IIb-IIIa. [Clin Ther. 1999] Nonimmunogenicity of eptifibatide, a cyclic heptapeptide inhibitor of platelet glycoprotein IIb-IIIa.

What is the renal impairment of eptifibatide?

Renal Impairment. Approximately 50% of eptifibatide is cleared by the kidney in patients with normal renal function. Total drug clearance is decreased by approximately 50% and steady-state plasma INTEGRILIN concentrations are doubled in patients with an estimated CrCl < 50 mL/min (using the Cockcroft-Gault equation).

Is eptifibatide a cyclic heptapeptide?

Eptifibatide is a cyclic heptapeptide containing 6 amino acids and 1 mercaptopropionyl (des-amino cysteinyl) residue. An interchain disulfide bridge is formed between the cysteine amide and the mercaptopropionyl moieties.