What does Calponin stain for?

Immunohistochemistry. The spindle cells characteristically stain for vimentin, smooth muscle actin, muscle-specific actin, calponin, and caldesmon. Desmin and anaplastic lymphoma kinase 1 (ALK1) staining is observed in about half of the cases, and p80 expression is also frequent.

What does p63 positive mean in breast?

P63 is a positive prognostic factor in endocrine-treated ER positive breast cancer and might influence responsiveness to endocrine treatment. Thus, p63 could be helpful as a predictive factor for endocrine therapy.

What is p63 a marker for?

Antibody against p63 is frequently used to aid in the diagnosis of prostate carcinoma, as well as in the identification of myoepithelial cells in other tissues including the breast. p63 is also a marker for squamous cell carcinoma.

What is p63 positive in myoepithelial cells?

The nuclear protein p63 has attracted much attention in recent reports. p63-positive myoepithelial cells have been shown to surround benign epithelial lesions and form a consistent, although discontinuous, rim around epithelial cells in carcinomas in situ.

What is p63 and Calponin?

p63 protein is a highly specific and sensitive marker of myoepithelial cells. • p63 protein and calponin can be used simultaneously in double staining system. • p63 protein can be used as significant marker of carcinoma in situ in CMTs.

Are myoepithelial cells cancerous?

Myoepithelial cells are natural tumor suppressors. Myoepithelial cells, which surround ducts and acini of glandular organs, form a natural border separating proliferating epithelial cells from basement membrane and underlying stroma, thus physically preventing tumor cell invasion.

What is p63 in immunohistochemistry?

Tumor protein 63 (p63) is a transcription factor of the p53 gene family involved in differentiation of several tissues including squamous epithelium. p63 immunohistochemistry is broadly used for tumor classification but published data on its expression in cancer is conflicting.

What does p63 negative mean?

p63 is negative in malignant tumors of the prostate. Striated muscle staining may be observed with p63. Interpretation. This test does not include pathologist interpretation, only technical performance of the stain.