What is Karyomegalic interstitial nephritis?
Karyomegalic interstitial nephritis (KIN) is a rare hereditary cause of chronic kidney disease. It typically causes progressive renal impairment with haemoproteinuria requiring renal replacement therapy before 50 years of age.
What does Karyomegalic mean?
Karyomegalic interstitial nephritis is a rare, genetic renal disease characterized by slowly progressive, chronic, tubulointerstitial nephritis, leading to end-stage renal disease before the age of 50 years, manifesting with mild proteinuria, glucosuria and, occasionally, urinary sediment abnormalities (mainly …
What is granulomatous interstitial nephritis?
Granulomatous interstitial nephritis (GIN) is a rare cause of acute kidney injury (AKI). Causes of GIN include sarcoidosis, drugs (NSAIDs, antibiotics), and infections (mycobacterial, fungal, bacterial, and viral). Renal involvement as an initial manifestation of sarcoidosis is another rare entity.
What is interstitial nephritis caused by?
Interstitial nephritis can be caused by an allergic reaction to a medication. Infections. Bacterial infections like E. coli, viral infections like HIV or herpes, syphilis, parasites, and exposure to fungi are all infections that are linked to interstitial nephritis.
What is interstitial nephritis symptoms?
Symptoms of interstitial nephritis Increased urine output. Blood in your urine or dark urine. Nausea or vomiting. Fever or rash. Elevated blood pressure.
What are symptoms of interstitial nephritis?
Symptoms
- Blood in the urine.
- Fever.
- Increased or decreased urine output.
- Mental status changes (drowsiness, confusion, coma)
- Nausea, vomiting.
- Rash.
- Swelling of any area of body.
- Weight gain (from retaining fluid)
What is the pathophysiology of nephritis?
The principal mechanism in acute tubulointerstitial nephritis is hypersensitivity reaction to drugs such as penicillins, nonsteroidal anti-inflammatory drugs (NSAIDs), and sulfa drugs. Another mechanism is acute cellular injury caused by infection, viral or bacterial, often associated with obstruction or reflux.