Is Dectin-1 a phagocytic receptor?

Dectin-1 is a key phagocytic receptor for fungi and triggers a massive oxidative burst in response to fungal exposure5,6,10,11. TLRs sense soluble microbial stimuli and are activated by dimerization of intracellular signalling domains.

What does Dectin-1 recognize?

Dectin-1 specifically recognizes soluble and particulate β(1→3)- and/or β(1→6)-linked glucans27; these are carbohydrate polymers with immunomodulatory activity that are found mainly in the cell walls of fungi, but also in plants and some bacteria.

Where is Dectin-1 found?

Dectin-1 Is a CLR found on monocytes and macrophages that recognizes Mycobacterium tuberculosis and fungal cell wall through binding to β-1,3-glucan polymer present in the fungal cell wall.

What does Dectin-1 bind?

Dectin-1 is a type II transmembrane protein which binds β-1,3 and β-1,6 glucans. It is expressed on most cells of the innate immune system and has been implicated in phagocytosis as well as killing of fungi by macrophages, neutrophils and dendritic cells.

Is Dectin 1 a TLR?

One example is the pair consisting of Dectin-1 and Toll-like receptor (TLR)2. Both of these receptors play important roles in the innate immune defense against fungal infections, which can cause life-threatening inflammatory reactions in children and immunocompromised individuals (15–19).

What are C type lectin receptors?

C-type lectin receptors (CLRs) are important pattern recognition receptors involved in recognition and induction of adaptive immunity to pathogens. Certain CLRs play an important role in viral infections as they efficiently interact with viruses.

What is the definition of phagocytosis in biology?

Listen to pronunciation. (FA-goh-sy-TOH-sis) The process by which a phagocyte (a type of white blood cell) surrounds and destroys foreign substances (such as bacteria) and removes dead cells.

Does Dectin-1 play a role in phagocytosis of yeast pathogens?

The phagocytosis of pathogens is a critical event in host defense, not only for clearance of the invading microorganism, but also for the subsequent immune response. We have examined Dectin-1, a proinflammatory nonopsonic receptor for β-glucans, and show that it mediates the internalization of β-glucan-bearing ligands, including yeast particles.

What is the function of dectin-1?

Dectin-1 belongs to the hemITAM family and can be found in the plasma membrane of various myeloid cells, including DCs, monocytes, and macrophages, as well as B cells. Activation of dectin-1 by fungal cell wall β-glucans stimulates phagocytosis, the production of ROS, and NFκB-mediated cytokine secretion.

How does Dectin-1 distinguish between soluble and particulate β-glucans?

The phagocytic synapse model was proposed to explain how Dectin-1 can distinguish between soluble and particulate β-glucans (Goodridge et al., 2011). Dectin-1 signals in a similar manner to the T cell antigen receptor (TCR), which transmits signals to activate T cells by associating with CD3 molecules.

What is the mechanism of phagocytosis?

Mechanisms of Fc receptor and dectin-1 activation for phagocytosis Phagocytosis is a key cellular process, both during homeostasis and upon infection or tissue damage.