What is Perhexiline used for?

Used in the treatment of unresponsive or refractory angina. Perhexiline increases glucose metabolism at the expense of free-fatty-acid metabolism, enhancing oxygen efficiency during myocardial ischaemia.

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What are the side effects of Perhexiline?

The severe adverse effects are peripheral neuropathy, papilloedema, hypoglycaemia and weight loss. Changes in liver enzymes occur frequently and some patients develop liver damage which can be fatal.

What is Perhexiline maleate?

Perhexiline maleate is an anti-anginal agent. Its mechanism of action as. an anti-anginal agent has not been fully elucidated in humans; however, in vitro studies suggest that perhexiline causes inhibition of myocardial.

What type of drug is Perhexiline?

Perhexiline (Pexsig) is a prophylactic antianginal agent used primarily in Australia and New Zealand. Perhexiline is thought to act by inhibiting mitochondrial carnitine palmitoyltransferase-1.

What is desvenlafaxine ER used for?

Desvenlafaxine is used to treat depression. Desvenlafaxine is in a class of medications called selective serotonin and norepinephrine reuptake inhibitors (SNRIs). It works by increasing the amounts of serotonin and norepinephrine, natural substances in the brain that help maintain mental balance.

What is isosorbide mononitrate?

Isosorbide mononitrate is used to prevent angina (chest pain) caused by coronary artery disease (heart disease). It does not work fast enough to relieve the pain of an angina attack that has already started. Isosorbide mononitrate belongs to the group of medicines called nitrates.

Who should not take desvenlafaxine?

Desvenlafaxine has not been studied in children. It should not be used in children younger than 18 years. The kidneys of older adults may not work as well as they used to.

Can desvenlafaxine cause high blood pressure?

Desvenlafaxine may increase blood pressure. Your blood pressure should be checked regularly while you are taking this medication.

What are side effects of isosorbide?

COMMON side effects

low blood pressure.
dizziness.
temporary redness of face and neck.
headache.
nervousness.
a feeling of pins and needles on skin.

What is isosorbide prescribed for?

Descriptions. Isosorbide mononitrate is used to prevent angina (chest pain) caused by coronary artery disease (heart disease). It does not work fast enough to relieve the pain of an angina attack that has already started.

What is desvenlafaxine used to treat?

What desvenlafaxine is used for?

How is perhexiline maleate used to treat severe angina pectoris?

Perhexiline maleate, which causes inhibition of myocardial fatty acid catabolism with a concomitant increase in glucose utilization, is particularly useful in the management of patients with severe angina pectoris.

Is perhexiline maleate soluble in methanol?

Perhexiline maleate 100mg tablets. Perhexiline maleate is 2-(2,2-Dicyclohexylethyl)piperidine maleate. Molecular formula is C19H35N,C4H4O4 and molecular weight of 393.6. Perhexiline maleate is a fine white crystalline powder. It is slightly soluble in water (0.1% to 1.0% w/w or 1-10mg/g). Soluble in chloroform and methanol.

Does perhexiline have any negative side effects?

While perhexiline exerts no significant negative inotropic or dromotropic effects, its short- and long-term use has hitherto been restricted because of complex pharmacokinetics and the eventual development, in many patients, of hepatitis and peripheral neuropathy.

How does perhexiline work?

Perhexiline is one member of a disparate family of drugs termed fatty acid oxidation inhibitors (FAOIs) due to their capacity to inhibit fatty acid metabolism in the myocardium and in other tissues ( Fig. 3 ).