What is treosulfan used for?

Medical Uses Treosulfan in combination with fludarabine is indicated as part of conditioning treatment prior to allogeneic haematopoietic stem cell transplantation (alloHSCT) in adults with malignant and non malignant diseases, and in children older than one month with malignant diseases.

What is fludarabine used for?

Fludarabine injection is used to treat chronic lymphocytic leukemia (CLL; a type of cancer of the white blood cells) in adults who have already been treated with at least one other medication and have not gotten better. Fludarabine injection is in a class of medications called purine analogs.

What is myeloablative conditioning?

Reduced intensity conditioning refers to a conditioning regimen that uses less chemotherapy and radiation than the standard regimen, which destroys the patient’s bone marrow cells, (a result known as myeloablation).

How is fludarabine given?

Fludarabine is given through a vein, intravenously, IV. The amount of fludarabine that you will receive depends on many factors, including your height and weight, your general health or other health problems, and the type of cancer or condition being treated. Your doctor will determine your dose and schedule.

Is fludarabine an immunosuppressant?

Abstract. Fludarabine is a nucleoside analog used in the treatment of hematologic malignancies that can induce severe and prolonged immunosuppression.

What is the difference between myeloablative and Nonmyeloablative?

Non-myeloablative transplants differ primarily in what happens prior to the transplant. Compared to myeloablative transplants, mini-transplants use much lower and less toxic doses of chemotherapy and radiation, followed by the infusion of donor stem cells.

What are the two types and symptoms of GVHD?

Rash, raised, or discolored areas, skin thickening or tightening (signs of cGvHD of the skin). Abdominal swelling, yellow discoloration of the skin and/or eyes, and abnormal blood test results (signs of cGvHD of the liver). Dry eyes or vision changes (signs of cGvHD of the eyes).