What is CD30 in cancer?

The CD30 protein may be found in higher than normal amounts on some types of cancer cells, including lymphoma cells. Knowing how much CD30 protein is on a patient’s cancer cells may help diagnose cancer and plan treatment. The CD30 protein is a type of tumor necrosis factor receptor and a type of tumor marker.

What is CD30 in pathology?

CD30, a 120-kDa cytokine receptor and transmembrane glycoprotein, is a member of the tumor necrosis factor (TNF) receptor superfamily. The protein is comprised of an extracellular domain, a transmembrane region and a cytoplasmic domain.

What is the treatment for lymphoproliferative disorder?

Treatment for lymphoproliferative can include medication, chemotherapy, immunoglobulin therapy, home-based therapies or a bone marrow transplant. The type of therapy chosen for your child will depend on the type of lymphoproliferative disorder and the health of your child.

What does CD20 positive B cells mean?

A protein found on B cells (a type of white blood cell). It may be found in higher than normal amounts in patients with certain types of B-cell lymphomas and leukemias. Measuring the amount of CD20 on blood cells may help to diagnose cancer or plan cancer treatment. CD20 is a type of tumor marker.

What does CD30 stand for in cancer?

CD30 was originally described as a marker of Hodgkin’s and Reed-Sternberg cells in Hodgkin’s lymphoma. Cloning and characterization of cDNAs encoding CD30 and its ligand (CD30L) established these proteins as members of the tumor necrosis factor receptor (TNFR) and tumor necrosis factor (TNF) superfa …

What is the cd30v variant of Hodgkin lymphoma?

Accessed November 26th, 2021. CD30: lymphocyte activation antigen important in diagnosis of classic Hodgkin’s lymphoma, anaplastic large cell lymphoma and embryonal carcinoma CD30v: variant form of CD30 which retains only the cytoplasmic domain; very little has been published about CD30v

Where is CD30 found in the body?

The ligand is present on activated T cells, resting B cells, granulocytes, and the medulla of the thymus (epithelial cells and Hassal’s corpuscles) as well as in various leukemia cells. The biological function of CD30 is pleiotropic but has come to be understood in the context of co-stimulatory signals.

How many binding sites does CD30 have?

“CD30 contains two binding sites with different specificities for members of the tumor necrosis factor receptor-associated factor family of signal transducing proteins”. The Journal of Biological Chemistry. 271 (22): 12852–8. doi: 10.1074/jbc.271.22.12852.