What is povidone K30?

Generic Name Povidone K30 DrugBank Accession Number DB14478 Background. A polyvinyl polymer of variable molecular weight; used as suspending and dispersing agent and vehicle for pharmaceuticals; also used as blood volume expander.

What is the difference between crospovidone and povidone?

Polyvinylpyrrolidone (PVP), also commonly called polyvidone or povidone, is a water-soluble polymer made from the monomer N-vinylpyrrolidone. As a food additive, PVP is a stabilizer and has E number E1201. PVPP (crospovidone) is E1202. It is also used in the wine industry as a fining agent for white wine or some beers.

What is K value in povidone?

Povidone is a chain polymer of 1-vinyl-2-pyrrolidone. It contains NLT 11.5% and NMT 12.8% of nitrogen (N: 14.01), calculated on the anhydrous basis. It has the nominal K-value of NLT 10 and NMT 120.

Is poloxamer 188 a surfactant?

Poloxamer P188 is a nonionic copolymer surfactant with a triblock structure, comprised of two hydrophilic segments, the poly(oxyethylene) (PEO), and a central hydrophobic segment, the poly(oxypropylene) (PPO), taken together by ether bonds.

What is Type B crospovidone?

Fine crospovidone grades (type B) increased the tensile strength of the respective tablets at a given compression pressure. The finer the crospovidone grade, the stronger the binding capacity. The addition of 5% Kollidon® CL weakened the tablets, compared to formulations without disintegrants (Figure 2b).

Does crospovidone affect the disintegration time of organic compounds?

Prolonged disintegration times could be compensated to a certain extent by the addition of crospovidone. Increasing concentrations of crospovidone led to shorter disintegration times. Formulations, containing a certain amount of Kollidon® CL, Kollidon® CL-F or Kollidon® CL-SF showed similar disintegrating properties at given compression conditions.

Where are povidones made?

From large volume povidones to innovative copovidones, crospovidones and polyvinylpyrrolidone, BASF Pharma Solutions is a leader in PVP manufacturing, packaging, and supply. BASF Kollidon® PVP products are manufactured according to cGMP, in three independent facilities in Asia, the US and Europe.

Do different grades of crospovidone differ in their compressibility?

Regarding their compressibility, hardly any differences between the tested crospovidone grades could be seen. Dedicated com pression pressures led to similar ejected solid fraction values. In contrastthe coarser crospovidone (Kollidon® CL), resulting in lower ejected solid fractions (Figure 2c).