What is Dichloroacetate sodium?

Description. Sodium Dichloroacetate is the sodium salt of dichloroacetic acid with potential antineoplastic activity. Dichloroacetate ion inhibits pyruvate dehydrogenase kinase, resulting in the inhibition of glycolysis and a decrease in lactate production.

Is DCA FDA approved?

While some experimental treatments have shown interesting results, DCA hasn’t yet been proven safe or effective for treating cancer. It’s not approved by the U.S. Food and Drug Administration (FDA) as a cancer treatment. Until further research is done, it’s not recommended to use DCA as an alternative cancer treatment.

What is DCA for cancer?

Oral dichloroacetate sodium (DCA) has been investigated as a novel metabolic therapy for various cancers since 2007, based on data from Bonnet et al that DCA can trigger apoptosis of human lung, breast and brain cancer cells.

What is sodium dichloroacetate used for?

Sodium dichloroacetate (DCA) is a mitochondrial pyruvate dehydrogenase kinase inhibitor, and is an orally absorbable small molecular compound for MELAS syndrome, and children with congenital lactic acidosis and other diseases that are treated in the clinic (Michelakis et al., 2008, 2010).

What is Dichloroacetate used for?

DCA has been used to treat inherited mitochondrial disorders that result in lactic acidosis, as well as pulmonary hypertension and several different solid tumors, the latter through its ability to reverse the Warburg effect in cancer cells and restore aerobic glycolysis.

Is Dichloroacetate FDA approved?

US Food and Drug Administration Approval There is not enough evidence that dichloroacetate is effective in the fight against cancer, and it has not been approved by the FDA for cancer treatment.

Why is Dichloroacetate toxic?

DCA stimulates the thiamine-dependent enzymes pyruvate dehydrogenase and α-ketoacid dehydrogenase. We postulated that hte neurotoxicity from chronic DCA administration could result from depletion of body thiamine stores and abnormal metabolism of oxalate, a known neurotoxin.

What effect does Dichloroacetate have on the Warburg effect?

DCA reverses the Warburg effect in human tumor cells by inhibiting PDKs, re-activating PDC and OXPHOS and decreasing pyruvate and lactate levels, leading to decreased expression of HIF1α (Kankotia & Stacpoole, 2014).

What is DCA drug used for?

DICHLOROACETATE (DCA) is a drug that has been used for decades to treat children who are born with mitochondrial diseases. Mitochondria are organelles found in human cells and they play an important role in the production of energy required for many cellular functions.

What is sodium dichloroacetate (DCA)?

Sodium dichloroacetate, or more commonly referred to as DCA, is a synthetic chemical compound that has recently gained attention because of positive studies involving cancer cells that were performed… Healing Cancer with Alternative Methods Menu Breast Health

Is sodium dichloroacetate an alternative cancer treatment?

This article concerns Sodium Dichloroacetate, or DCA, which has shown clear potential as an alternative cancer treatment, according to researchers at both the University of Alberta and the University of Florida; in particular, DCA has been used in a number of trials with people suffering from brain cancer, or glioblastoma, GBM.

Do you produce and sell sodium dichloroacetate?

We produce and sell Sodium Dichloroacetate in various forms and packages. You can purchase capsules, powder and other DCA salts. Read more Our Labaratory All the products we offer are produced by us in our own laboratory.

What is the CID for sodium dichloroacetate?

Sodium dichloroacetate PubChem CID 517326 Parent Compound CID 6597 (Dichloroacetic acid) Component Compounds CID 6597 (Dichloroacetic acid) CID 53605 Date s Modify 2021-07-10 Create 2005-03-27