What does subiculum mean?
Medical Definition of subiculum : a part of the parahippocampal gyrus that is a ventral continuation of the hippocampus and is situated ventrally and medially to the dentate gyrus also : a section of this that borders the hippocampal sulcus.
What is the function of the subiculum?
The subiculum is an integral part of the limbic memory system, responsible for memory retrieval (22) and spatial encoding (23–26). Similar to CA1 neurons, subicular neurons are place cells that respond when the animal is in a particular location in space.
Where is subiculum located?
mesial temporal lobe
The subiculum (plural: subicula) is located in the mesial temporal lobe and is a subdivision of the hippocampal formation, along with Ammon’s horn, the entorhinal cortex and the hippocampus proper. It is the predominant output source of the hippocampal formation.
What is the ventral subiculum?
The ventral subiculum (VSub) has widespread projections to the amygdala that target all three nuclei of the BNC (Fig. 8B; McDonald, 1998). The ventral part of CA1 (VCA1), located adjacent to the VSub, has projections to the BNC that are lighter than those of VSub.
Where do subiculum projects go?
The proximal part of the septal subiculum projects to the anteromedial nucleus of the thalamus, but the distal part projects to the anterior thalamic complex. The latter projection is reciprocated.
What are the main areas the subiculum projects to?
Ventral subiculum projects to the hypothalamus via the postcommissural fornix, the medial corticohypothalamic tract and the amygdala; these projections innervate the medial preoptic area, the ventromedial and dorsomedial nuclei, and ventral premammillary and medial mammillary nuclei.
What can damage hippocampus?
Damage to hippocampus can occur through many causes including head trauma, ischemia, stroke, status epilepticus and Alzheimer’s disease.
What disorders are associated with the hippocampus?
Neuroimaging and neuropsychological studies have, among other observations, implicated the hippocampal formation in Alzheimer’s disease, temporal lobe epilepsy (TLE), cognitive ageing, post-traumatic stress disorder (PTSD), transient global amnesia, schizophrenia, and depressive and anxiety disorders.
Where is CA1 neurons project?
The pyramidal neurons of the CA1 area represent the main output of the hippocampus. They heavily project to the subiculum and innervate the deeper layers of entorhinal cortex (Amaral and Witter, 1989).