How is nanotechnology used in targeted drug delivery system?
The application of nanotechnology for drug delivery provides the potential for enhanced treatments with targeted delivery and fewer side effects. Nanotechnology drug delivery applications occur through the use of designed nanomaterials as well as forming delivery systems from nanoscale molecules such as liposomes.
What is targeted drug delivery system?
Targeted drug delivery is a system of specifying the drug moiety directly into its targeted body area (organ, cellular, and subcellular level of specific tissue) to overcome the aspecific toxic effect of conventional drug delivery, thereby reducing the amount of drug required for therapeutic efficacy.
What are the nano tools used for targeted drug delivery?
Nanoparticles used in drug delivery system
- Chitosan. Chitosan exhibits muco-adhesive properties and can be used to act in the tight epithelial junctions.
- Alginate.
- Xanthan gum.
- Cellulose.
- Liposomes.
- Polymeric micelles.
- Dendrimers.
- Inorganic nanoparticles.
What is nanoparticles in Ndds?
Nanoparticles (NP) are colloidal drug delivery system which are formulated by natural, synthetic, and semi synthetic polymers. Particle size of NP ranges from 10 nm to 1,000 nm in diameter11. This colloidal drug delivery system shows different inner structure.
What system is used by nanotechnology for drug delivery?
Nano-carrier system (NCS) encapsulates or adsorbs a drug, a therapeutic foreign gene molecule on its surface, and also couples a specific targeting molecule to the surface of the nano-carrier and then binds to a cell surface-specific receptor through a targeting molecule.
Why are nanoparticles useful for drug delivery?
Due to their small size and large surface area, drug nanoparticles show increase solubility and thus enhanced bioavailability, additional ability to cross the blood brain barrier (BBB), enter the pulmonary system and be absorbed through the tight junctions of endothelial cells of the skin (Kohane, 2007).
What is automated drug delivery system?
An “automated drug delivery system” (ADDS) means a mechanical system that performs operations or activities, other than compounding or administration, relative to the storage, dispensing, or distribution of drugs.
Why targeted drug delivery is important?
The system is based on a method that delivers a certain amount of a therapeutic agent for a prolonged period of time to a targeted diseased area within the body. This helps maintain the required plasma and tissue drug levels in the body, thereby preventing any damage to the healthy tissue via the drug.
What are the application of nanoparticles?
Nanoparticles are used increasingly in catalysis to boost chemical reactions. This reduces the quantity of catalytic materials necessary to produce desired results, saving money and reducing pollutants. Two big applications are in petroleum refining and in automotive catalytic converters.
How is graphene used in drug delivery?
The high level of chemical reactivity vested in the planar structure of graphene can be used to load various drugs and biomolecules with maximum radical scavenging effect. The integration of graphene and polymers brings electrical conductivity to scaffolds, making them ideal for cardiac or neuronal tissue engineering.
Why is graphene used for drug delivery?
The use of graphene in therapeutics delivery is based upon its particular properties. Its high surface-area to volume ratio, polyaromatic structure and the ease with which various forms can be functionalised offers capacity and flexibility for cargo loading, transport and targeting to tissues.
What is nanoparticle drug delivery system?
Nanoparticles act as a vehicle on which the drugs are encapsulated within or chemically bonded • Usage of engineered nanoparticles to deliver drugs in a more targeted, efficient way, with less unpleasant side effects to patients Liposome: Most commonly used nanoparticle Nano Drug Delivery System Let’s look at Liposome as an example 7.
How to develop targeted nanoparticles?
Schematic diagram for the development of targeted nanoparticles Using a platform technology we first generate an activated nanoparticle. In a second reaction the targeting agent (antibodies) is conjugated to the outer surface of the nanoparticle with the help of Linkers or Spacers.
3. INTRODUCTION : ‘Targeted drug delivery system is a special form of drug delivery system where the medicament is selectively targeted or delivered only to its site of action or absorption and not to the non-target organs or tissues or cells.’
What are the different methods of drug targeting?
STRATEGIES OF DRUG TARGETING 1) Passive Targeting : • Drug delivery systems which are targeted to systemic circulation are characterized as Passive delivery systems. • In this technique drug targeting occurs because of the body’s natural response to physicochemical characteristics of the drug or drug carrier system.