What is the EC50 of acetylcholine?
Acetylcholine (ACh) and muscarine induced a concentration-dependent depolarization of these cells. The EC50 values were respectively 159 +/- 54 microM and 0.7 +/- 0.15 microM.
What is the EC50 of carbachol?
3 Carbachol induced concentration-dependent contractions (EC50 = 0.021 +/- 0.004 microm) that were inhibited by 0.3 microm atropine to a non-competitive manner (decreased maximal response, EC50 value = 0.26 +/- 0.04 microm, K(e) = 0.026 microm).
What is the pharmacology of acetylcholine?
Acetylcholine (ACh) is a neurotransmitter that functions in both the PNS and the CNS. The ANS (sympathetic and parasympathetic) uses acetylcholine to generate a nerve impulse. In PNS, ACh mainly acts on the muscular system by activating muscle contraction after being released in the neuromuscular junction.
What is the effect of acetylcholine on muscarinic receptors?
[1] The molecule acetylcholine activates muscarinic receptors, allowing for a parasympathetic reaction in any organs and tissues where the receptor is expressed.
What is the EC50 of ethanol?
The potentiation was concentration-dependent over the concentration range of 10-100 mM; the EC50 for this potentiation was 57 mM ethanol.
What receptors does carbachol use?
Carbachol, a synthetic derivative of choline, acts primarily by stimulating muscarinic receptors. It also releases acetylcholine at certain neuroeffector junctions and ganglia.
What class of neurotransmitter is acetylcholine?
Acetylcholine is the primary neurotransmitter of the parasympathetic nervous system. In the brain, acetylcholine functions as a neurotransmitter and as a neuromodulator….Acetylcholine.
| Clinical data | |
|---|---|
| Other names | ACh |
| Physiological data | |
| Source tissues | motor neurons, parasympathetic nervous system, brain |
What are the EC50 values for physostigmine and Tacrine?
The EC50 values were respectively 159 +/- 54 microM and 0.7 +/- 0.15 microM. Physostigmine (1 microM) or tacrine (1 microM) induced a marked shift in the concentration-response curve for ACh. Both drugs were equipotent in this respect. The EC50 values for ACh became, respectively, 2.4 +/- 1.5 microM and 3 +/- 0.9 microM.
What is the EC50 value of atropine?
The EC50 values for ACh became, respectively, 2.4 +/- 1.5 microM and 3 +/- 0.9 microM. The depolarizing effect of ACh was completely blocked by atropine, confirming the involvement of a receptor of the muscarinic type.
What is the concentration of acetylcholine and muscarine?
Acetylcholine (ACh) and muscarine induced a concentration-dependent depolarization of these cells. The EC50 values were respectively 159 +/- 54 microM and 0.7 +/- 0.15 microM.
Is acetylcholine a depolarizing agent?
Acetylcholine (ACh) and muscarine induced a concentration-dependent depolarization of these cells. The EC50 values were respectively 159 +/- 54 microM and 0.7 +/- 0.15 microM. Physostigmine (1 microM) or tacrine (1 microM) induced a marked shift in the concentration-response curve for ACh.