What are the complications of filgrastim?

Filgrastim injection products may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

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redness, swelling, bruising, itching or a lump in the place where the medication was injected.
bone, joint, back, arm, leg, mouth, throat, or muscle pain.
headache.
rash.
constipation.
diarrhea.
nausea.

Does filgrastim cause bone pain?

Filgrastim stimulates the bone marrow to produce many white blood cells, which can lead to pain in the bones. This pain is often felt in the bones of the thighs, hips, and upper arms.

Can filgrastim cause leukemia?

This medicine may cause blood or bone marrow problems (eg, myelodysplastic syndrome, acute myeloid leukemia) in patients with breast or lung cancer.

Is bone marrow affected by chemotherapy?

Chemotherapy. Certain chemotherapy drugs can damage your bone marrow — the spongy material found in your bones. Your bone marrow makes blood cells, which grow rapidly, making them very sensitive to the effects of chemotherapy. Chemotherapy kills many of the cells in your bone marrow, but the cells recover with time.

Can you have too much filgrastim?

Filgrastim Usage Too little filgrastim may not protect you against infections, and too much filgrastim may cause too many neutrophils to be in your blood. Your doctor will determine your/your child’s correct dose based on your body weight.

How do you treat side effects of filgrastim?

Filgrastim Self-Care Tips: Ask your healthcare provider if you may take a mild pain medicine to relieve this. Acetaminophen (Tylenol®) may help. Apply a warm compress if you have any pain, redness or swelling at the injection site, and notify your doctor. This medication causes little nausea.

How long does it take for filgrastim to wear off?

Studies show that it may take 1 to 2 weeks for your neutrophil level to return to normal after taking Neulasta following a round of chemotherapy. Neutrophils are a type of white blood cell that work to fight off infections. The drug’s effects last in your system for about 1 to 2 weeks.

How long does bone pain last after filgrastim?

Bone pain caused by Neulasta lasts at least 8 days for 49% of the patients, and most likely longer for a large number of patients.

What medications can increase WBC?

Drugs that may increase WBC counts include:

Beta adrenergic agonists (for example, albuterol)
Corticosteroids.
Epinephrine.
Granulocyte colony stimulating factor.
Heparin.
Lithium.

What drugs affect bone marrow?

Other chemicals/drugs known to cause bone marrow suppression include chloramphenicol, meclofenamic acid, phenylbutazone, quinidine, trimethoprim-sulfadiazine, albendazole and fenbendazole (Manyan et al., 1972).

How can I protect my bone marrow from chemo?

COSELA™ (trilaciclib) can help protect the blood-forming cells and lower your risk of bone marrow suppression, a harmful side effect of chemo. COSELA is a prescription medicine used to help reduce the occurrence of low blood cell counts caused by damage to bone marrow from chemotherapy.

How long can you take filgrastim?

Indications and dose 5 micrograms/kg daily until neutrophil count in normal range, usually for up to 14 days (up to 38 days in acute myeloid leukaemia), to be started at least 24 hours after cytotoxic chemotherapy. Preferably given by subcutaneous injection; if given by intravenous infusion, administer over 30 minutes.

What are the side effects of filgrastim?

In 100 people receiving Filgrastim, 3 or fewer may have: Chest pain, shortness of breath Damage to the bone marrow (irreversible) which may cause infection, bleeding, may require transfusions Rupture of the spleen causing sudden or severe pain in the left side of abdomen spreading up to your shoulder

Can I take filgrastim after a bone marrow transplant?

If you also receive chemotherapy or bone marrow transplant: Do not use filgrastim within 24 hours before or 24 hours after you receive chemotherapy, or within 24 hours after a bone marrow transplant. Other drugs may affect filgrastim, including prescription and over-the-counter medicines, vitamins, and herbal products.

What is the pharmacokinetics of filgrastim?

Filgrastim exhibits nonlinear pharmacokinetics with a short half-life of 3.5 hours, with filgrastim concentration and neutrophil count being the determinants of clearance.[16] The kidneys clear the drug. The bioavailability of filgrastim after subcutaneous administration is 60 to 70%.

What are the uses of filgrastim?

Filgrastim is used to treat neutropenia, a lack of certain white blood cells caused by cancer, bone marrow transplant, receiving chemotherapy, or by other conditions. Filgrastim may also be used for purposes not listed in this medication guide.