What kind of mutation does a tautomeric shift cause?

A tautomeric shift in one strand has produced a transition mutation in the complementary strand. If the mutation occurs in the germline, it will be transmitted to future generations. IMPORTANT: Note that a tautomeric shift is not itself a mutation, but a transient change to an alternative form of the molecule.

What is Tautomerization in mutation?

(a) Tautomerism: Tautomers are the alternate forms of bases and are produced by rearrangements of electrons and protons in the molecules (Fig. 6.46). Tautomerism is caused by certain chemical mutagens. In the next replication purines pair with pyrimidines and the base pair is altered at a particular locus.

What is Deamination mutation?

Deamination is removing the amino group from the amino acid and converting to ammonia. Since the bases cytosine, adenine and guanine have amino groups on them that can be deaminated, Deamination can cause mutation in DNA.

What type of mutations are caused by tautomeric shifts of nitrogenous bases?

transition mutation – change of one purine/pyrimidine pair to the other purine/pyrimidine pair. This can happen when one base member of a complementary pair undergoes a tautomeric shift during DNA replication, causing it to mispair.

What is tautomeric effect?

Tautomerism is a phenomenon where a single chemical compound tends to exist in two or more interconvertible structures that are different in terms of the relative position of one atomic nucleus which is generally the hydrogen.

What is frameshift insertion mutation?

Definition. A frameshift mutation in a gene refers to the insertion or deletion of nucleotide bases in numbers that are not multiples of three. This is important because a cell reads a gene’s code in groups of three bases when making a protein.

What is a tautomeric shift in biology?

Tautomeric shift is an intramolecular electron shift that changes the bonding structure of the molecule. How may it lead to a mutation? It allows hydrogen bonding of normally noncomplementary bases. It allows deletion of one or more bases in the template strand of DNA.

What is isomerization mutation?

The spontaneous isomerization of a nitrogen base to an alternative hydrogen-bonding form, possibly resulting in a mutation. Reversible shifts of proton position in a molecule. Bases in nucleic acids shift between keto and enol forms or between amino and imino forms.

What is the mechanism of tautomerization?

In most cases, the reaction occurs by the migration of Zinc atom of hydrogen accompanied by a change of location of a double bond. In a solution of a compound capable of tautomerization, the equilibrium between the two tautomers is created.

What does base shift shift between?

Bases in nucleic acids shift between keto and enol forms or between amino and imino forms. Click to see full answer. Considering this, what is Tautomeric shift how may it lead to a mutation?