Does a negative Kveim test exclude sarcoidosis?

The Kveim test appears to be based on an immunologic reaction associated with persistent lymphadenopathy of diverse causes and is not specific for sarcoidosis.

What is the pathogenesis of sarcoidosis?

Sarcoidosis is a multisystem disorder of unknown etiology characterized by the accumulation of T lymphocytes, mononuclear phagocytes, and noncaseating granulomas in involved tissues [1,2].

What are the five stages of sarcoidosis?

The Siltzbach classification system defines the following five stages of sarcoidosis: stage 0, with a normal appearance at chest radiography; stage 1, with lymphadenopathy only; stage 2, with lymphadenopathy and parenchymal lung disease; stage 3, with parenchymal lung disease only; and stage 4, with pulmonary fibrosis …

What is the Kveim test?

The Kveim test, Nickerson-Kveim or Kveim-Siltzbach test is a skin test used to detect sarcoidosis, where part of a spleen from a patient with known sarcoidosis is injected into the skin of a patient suspected to have the disease.

What is Kveim-Siltzbach (KS) test?

In recognition of their landmark contributions, the procedure is now commonly referred to as the Kveim-Siltzbach (KS) test Further confirmation of the validity of the KS test has continued to accumulate in studies from centers in Europe. Asia, and the United States, where the procedure is routinely performed as the first diagnostic study.

What are the side effects of the Kveim Siltzbach test?

Although sometimes trou- bling to patients who readily form keloid scars, a 3-4 mm scar is the only untoward side effect of the KS test. Reports of False-Positive Kveim-Siltzbach Tests Beginning in 1955 and continuing for about 20 years, with a veritable deluge from 1970 to 1972, reports of false-positive KS tests were published.

How accurate is the Kveim-Siltzbach test in the diagnosis of sarcoidosis?

[The Kveim-Siltzbach test in sarcoidosis] In the present study the Kveim-Siltzbach test showed high sensitivity in the diagnosis of sarcoidosis. This fact, together with the high specificity observed in other studies, makes the test a very useful tool for the non-invasive diagnosis of sarcoidosis.