How do neurotrophins affect apoptosis?
For neurotrophins, their primary function in sustaining the viability of neurons is counterbalanced by a receptor mechanism to eliminate cells by an apoptotic mechanism.
What is the role of neurotrophins in the developing brain?
The neurotrophins are a family of proteins that regulate development, maintenance, and function of vertebrate nervous systems. They serve as survival factors to ensure a match between the number of surviving neurons and the requirement for appropriate target innervation and also regulate cell fate decisions.
Do neurotrophins induce apoptosis?
Neurotrophins induce apoptosis of neurons expressing p75 in the absence of trk receptors.
What do neurotrophins assist with during neural development?
Neurotrophins promote cell survival and differentiation during neural development. These effects are primarily conveyed through Trk receptor activation. Paradoxically, neurotrophins can also induce cell death.
How do neurotrophins prevent cell death?
Object: Neurotrophins prevent the death of neurons during embryonal development and have potential as therapeutic agents. During development, neuronal death occurs only by apoptosis and not by necrosis. Following injury, however, neurons can die by both processes.
Do all neurons receive neurotrophins Why or why not?
Only those neurons that obtain sufficient neurotrophins survive. Thus, the final number of neurons innervating a target reflects the availability of neurotrophins.
Do neurotrophins inhibit proliferation?
Neurotrophins regulate proliferation and survival of two microglial cell lines in vitro. Exp Neurol.
Do neurotrophins prevent apoptosis?
Abstract. Object: Neurotrophins prevent the death of neurons during embryonal development and have potential as therapeutic agents. During development, neuronal death occurs only by apoptosis and not by necrosis. Following injury, however, neurons can die by both processes.
Do all neurons receive neurotrophins?
What are two main neurotrophins?
There are two classes of receptors for neurotrophins: p75 and the “Trk” family of Tyrosine kinases receptors.