How do you do diazotization titration?
Principle. This method involves reacting sodium nitrite with the aromatic primary amine in the sample to turn it into diazonium salt. A solution of amine is added to an acid solution at 0-5 °C accompanied by the addition of sodium nitrite.
What are diazotization titration give procedure involved and application of these titration?
Diazotization Titration are used to determination of primary aromatic amine compound. Reaction are performed in ice both at temp. 0-5 c. End point is determined by the starch iodine paper or by potentiometric method.
What is the diazotization process?
What is Diazotization? The chemical process used in converting a primary aromatic amine into the corresponding diazonium salt of the amine is commonly referred to as diazotization. This process is also known as ‘diazotization’.
What are the types of diazotization titration?
5. Slow diazotizable groups: sulpha groups, carboxylic groups and nitrogen oxide group. 6. Fast diazotizing groups: anilide, toluidine and aminophenol.
What is the temperature of diazotization?
between 0 – 5 °C.
Diazotization is usually carried out at low temperatures between 0 – 5 °C. We have to maintain low temperatures because if the temperature is above 5 °C, diazonium salts which are in aqueous solution tend to decompose explosively.
Which method is used to determination of procaine *?
Summary. A semi-micro method for the determination of procaine in procaine-penicillin and in its suspensions in arachis oil is given. The method is based upon extraction of procaine base with chloroform followed by acidification of the extract and titration with sodium nitrite solution.
What is the other name of diazotization titration?
Nitrite Titration
Diazotization Titration or Nitrite Titration: Diazotization is used in the analysis of aromatic compounds containing an amino group in the molecules.
Why does diazotization Titration require low temperature?
Diazotization is usually carried out at low temperatures between 0 – 5 °C. We have to maintain low temperatures because if the temperature is above 5 °C, diazonium salts which are in aqueous solution tend to decompose explosively. On the other hand, if the temperatures are too low crystallisation can occur.
What is the name of NaNO2?
Sodium nitrite
Sodium nitrite is an inorganic compound with the chemical formula NaNO2….CHEBI:78870 – sodium nitrite.
| ChEBI Name | sodium nitrite |
|---|---|
| ChEBI ID | CHEBI:78870 |
| Definition | An inorganic sodium salt having nitrite as the counterion. Used as a food preservative and antidote to cyanide poisoning. |
| Stars | This entity has been manually annotated by the ChEBI Team. |
What is diazotization titration used for?
Diazotization Titration or Nitrite Titration: Diazotization is used in the analysis of aromatic compounds containing an amino group in the molecules. This analysis is based on the reaction between aromatic primary amine (–NH2), HONO, in presence of excess mineral or inorganic acids.
What is the best method for the titration of phthalylsulphathiazole?
Procedure : Weigh accurately about 0.5 g of phthalylsulphathiazole and heat on a water-bath for 2 hours after the addition of 10.0 ml of sodium hydroxide solution. Cool the contents of the flask to 15°C in an ice-bath, add to it 10.0 ml of water and 20.0 ml of hydrochloric acid and carry out the titration slowly with 0.1 M sodium nitrite solution.
What is the mechanism of diazotisation?
Mechanism of Diazotisation 7. CONDITION FOR DIAZOTIZATION RATE OF TITRATION Different amino compound react with HONO at different rates NaNO2 added from the burette needs time to react with amino group accumulating in the solution Amines are classified as rapidly, slowly diazotisable depending on the rate of conversion into azo compounds.
What is the titration method for nitrous acid?
It uses the Titrant – sodium nitrite hence the method is sodium nitrite titration/Nitrite titration. The first involves is the addition of sodium nitrite to hydrochloric acid cause the formation of nitrous acid