Is antiretroviral drugs safe during pregnancy?
All pregnant women with HIV should take HIV medicines throughout pregnancy for their own health and to prevent perinatal transmission of HIV. (HIV medicines are called antiretrovirals). Perinatal transmission of HIV is also called mother-to-child transmission of HIV. Most HIV medicines are safe to use during pregnancy.
How the nevirapine syrup help the child?
In many developing countries, a two-dose regimen of nevirapine (NVP) around the time of birth is advocated as the most cost-effective way to prevent mother to child HIV transmission. One dose is taken by the mother at the onset of labour and one dose is given to her baby, between 48 and 72 hours after birth.
Why is nevirapine contraindicated in pregnancy?
Severe and sometimes fatal hepatotoxicity has been reported in pregnant women receiving this drug long-term as part of a combination antiretroviral regimen. Women, especially those with CD4+ counts greater than 250 cells/mm3, have a greater risk of developing hepatotoxicity.
How long should I give my baby nevirapine?
Your baby will take Nevirapine every day for the first six weeks after birth. When you are taking ARVs and are virally suppressed, exclusive breastfeeding is best for your baby. This means feeding your baby your breast milk only for the first six months.
What is a common side effect of antiretrovirals?
Recommended
| Protease Inhibitors (PIs) | Common Side Effects |
|---|---|
| amprenavir (Agenerase) | Nausea, vomiting, liver damage, skin rash |
| atazanavir (Reyataz; also included in Evotaz) | Nausea, vomiting, diarrhea, jaundice, gall bladder and kidney stones, liver damage, skin rash, increase in cholesterol, changes in heart rhythm |
Is TLD the best ARV?
TLD is more durable, featuring a higher drug-resistance barrier compared to NNRTIs and older integrase inhibitors. Therefore, the risk of drug resistance and the need for early switch to the costlier and more complicated second-line regimens are much lower than with TLE. TLD is more convenient to take.
What time should I give my baby nevirapine?
When should a baby stop nevirapine?
Women are counseled to stop breast-feeding their infants by the end of 6 months. Infants receive their last dose of NVP at either 24 weeks of age or 1 week after breast-feeding cessation, whichever occurs first, and have follow-up visits until the infant is 32 weeks old.
What is NVP in pregnancy?
Nausea and vomiting of pregnancy (NVP) is a debilitating condition affecting many pregnant women. Up to 90% of pregnant women will experience NVP of varying severity, with symptoms generally starting around 4–9 weeks of gestation, peaking around the 7th to 12th week, and subsiding by the 16th week.