Is halothane a Haloalkane?
Halothane is a haloalkane comprising ethane having three flouro substituents at the 1-position as well as bromo- and chloro substituents at the 2-position. It has a role as an inhalation anaesthetic. It is a haloalkane, an organofluorine compound, an organochlorine compound and an organobromine compound.
What is halothane hepatitis?
Type II hepatotoxicity (also called halothane hepatitis) is associated with massive centrilobular liver necrosis that leads to fulminant liver failure; the fatality rate is 50%. Clinically, it is characterized clinically by fever, jaundice, and grossly elevated serum transaminase levels.
How does halothane cause arrhythmia?
When respiration is depressed by halothane, the resultant retention of carbon dioxide may give rise to cardiac irregularities of sympathetic origin4 5 7. These include bigeminal rhythm, multifocal ventricular extrasystoles and multifocal ventricular tachycardia.
How is halothane metabolized?
Current Concepts in Drug Metabolism and Toxicology Halothane is metabolized extensively in hepatocytes by CYP 2E1 and, to a lesser extent, via CYP 2A6 to form trifluoroacetyl chloride, which is chemically reactive and forms trifluoroacetyl adducts with proteins.
How do you use halothane?
Fluothane (halothane) produces moderate muscular relaxation. Muscle relaxants are used as adjuncts in order to maintain lighter levels of anesthesia. Fluothane (halothane) augments the action of nondepolarizing relaxants and ganglionic-blocking agents. Fluothane (halothane) is a potent uterine relaxant.
How do you make halothane?
The commercial synthesis of halothane starts from trichloroethylene, which is reacted with hydrogen fluoride in the presence of antimony trichloride at 130 °C to form 2-chloro-1,1,1-trifluoroethane. This is then reacted with bromine at 450 °C to produce halothane.
How does halothane work?
Fluothane (halothane) increases cerebrospinal-fluid pressure. Fluothane (halothane) produces moderate muscular relaxation. Muscle relaxants are used as adjuncts in order to maintain lighter levels of anesthesia. Fluothane (halothane) augments the action of nondepolarizing relaxants and ganglionic-blocking agents.
What is the side effect of halothane?
Cardiorespiratory instability (i.e., hypotension, bradycardia), sensitizing the myocardium to catecholamine-induced arrhythmias, and mild liver dysfunction are relatively common side effects of halothane.
How is halothane made?
Synthesis. The commercial synthesis of halothane starts from trichloroethylene, which is reacted with hydrogen fluoride in the presence of antimony trichloride at 130 °C to form 2-chloro-1,1,1-trifluoroethane. This is then reacted with bromine at 450 °C to produce halothane.
What is halothane What is it used for?
Fluothane (halothane) is an inhalation anesthetic indicated for the induction and maintenance of general anesthesia. The brand name Fluothane is no longer available in the U.S. Generic versions may be available.
What is the systematic name of halothane?
CHEBI:5615
| Synonyms | Sources |
|---|---|
| 2-bromo-2-chloro-1,1,1-trifluoroethane | NIST Chemistry WebBook |
| bromochlorotrifluoroethane | NIST Chemistry WebBook |
| Fluothane | NIST Chemistry WebBook |
| Halothane | KEGG COMPOUND |