What are ballooned neurons?
Ballooned neurons are histological features of several neurodegenerative diseases of the central nervous system. We describe the immunocytochemical staining of ballooned neurons in Pick’s disease, unclassified dementia, corticonigral degeneration, pigment-spheroid degeneration and Alzheimer’s disease.
What are achromatic neurons?
Abstract. Achromatic neurons (AN) in the cerebral cortex are a characteristic feature of several neurodegenerative conditions including Pick’s disease, corticobasal degeneration and some cases of primary progressive aphasia.
What are NFTs in the brain?
Neurofibrillary tangles (NFTs) are aggregates of hyperphosphorylated tau protein that are most commonly known as a primary biomarker of Alzheimer’s disease. Their presence is also found in numerous other diseases known as tauopathies. Little is known about their exact relationship to the different pathologies.
Which disease can cause dementia?
Common causes of dementia are:
- Alzheimer’s disease. This is the most common cause of dementia.
- Vascular dementia.
- Parkinson’s disease.
- Dementia with Lewy bodies.
- Frontotemporal dementia.
- Severe head injury.
What happens Chromatolysis?
Chromatolysis is a reactive change that occurs in the cell body of damaged neurons, involving the dispersal and redistribution of Nissl substance (rough endoplasmic reticulum and polyribosomes) in order to meet an increased demand for protein synthesis such as is required to regenerate axons.
Where are NFTs found?
NFTs are initially and most densely distributed in the medial aspect and in the pole of the temporal lobe; they affect the entorhinal cortex and the hippocampus most severely (however, Braak et al found that in sporadic AD, tauopathy may appear first in the lower brainstem rather than in the transentorhinal region ).
What are NFTs Alzheimers?
Neurofibrillary tangles (NFTs) are a characteristic neuropathological lesion of Alzheimer’s disease (AD). They are composed of a highly-phosphorylated form of the microtubule-associated protein tau.
Where are neurofibrillary tangles found?
Neurofibrillary tangles are found within the cell bodies of affected neurons in the hippocampus, neocortex, and certain other regions of the cerebral hemispheres and brain stem.