What does a high lipoprotein A mean?
A high lipoprotein (a) level may mean you are at risk for heart disease. There are no specific treatments to lower lipoprotein (a). Your level of lipoprotein (a) is determined by your genes and is not affected by your lifestyle or by most medicines.
What should I do if I have high lipoprotein A?
Other treatments shown to help lower Lp(a) levels include:
- PCSK9 inhibitors. These reduce levels by 20-30%, but they are not currently licenced for lowering Lp(a).
- Lipoprotein apheresis. This is a weekly-fortnightly treatment similar to renal dialysis which can reduce Lp(a) levels by up to 75%.
How do you reduce lipoprotein A?
To achieve Lp(a) reduction, one evidence-based approach is to initiate therapy with low-dose aspirin and extended-release niacin, titrated from 0.5 g up to 2 g over several weeks.
Is high Lp a death sentence?
You can maintain a healthy heart at any age Being diagnosed with high cholesterol, heart disease or even FH is not a death sentence. Every person’s health considerations are unique, but by working with your doctor, you can come up with a plan to help manage your health and maintain the strongest heart possible.
How common is high lipoprotein A?
Indeed, elevated Lp(a) is the most common genetic dyslipidemia, with nearly 1 in 5 individuals affected in the United States [ie, based on Lp(a) >50 mg/dL or >120 nmol/L].
How is lipoprotein A inherited?
Lipoprotein(a) is an LDL-like core lipoprotein particle covalently bound to a large glycoprotein, apo(a), largely under genetic control by the LPA gene locus, with serum levels little affected by statins, diet or exercise.
Do statins lower lipoprotein A?
Long term statin treatment reduces lipoprotein(a) concentrations in heterozygous familial hypercholesterolaemia.
Does everyone have lipoprotein A?
Lp(a) is common in the general population, but there are racial differences that may explain why some people are at higher risk of heart disease. South Asians have the highest prevalence, with 35 percent of their population having Lp(a) greater than 50 milligrams per deciliter, followed by Africans at 30 percent.
Is high lipoprotein a hereditary?
Importance Lipoprotein(a) is a highly heritable biomarker independently associated with atherosclerotic cardiovascular disease (ASCVD). It is unclear whether measured lipoprotein(a) or genetic factors associated with lipoprotein(a) can provide comparable or additional prognostic information for primary prevention.