What does ATRA stand for in medical terms?

The most important drug in the initial treatment of APL is all-trans-retinoic acid (ATRA). This is usually combined with one of these: Arsenic trioxide (ATO), another non-chemo drug.

How is ATRA administered?

ATRA is given by mouth (in capsule form). One size capsule – 10mg, do not crush chew or dissolve capsules.

What is the chemo drug ATRA?

ATRA. ATRA is a form of vitamin A that is typically part of the initial (induction) treatment of APL. It is given either along with chemo, or along with arsenic trioxide for the initial treatment of APL.

How does ATRA work in APL?

All-Trans Retinoic Acid (ATRA) This drug, a vitamin A derivative, has become a standard component of induction therapy for APL. ATRA targets and eliminates the PML/RARα abnormality. This treatment causes a marked decrease in the concentration of leukemic blast cells in the marrow, and a remission frequently follows.

What is promyelocytic leukemia?

An aggressive (fast-growing) type of acute myeloid leukemia in which there are too many immature blood-forming cells in the blood and bone marrow. It is usually marked by an exchange of parts of chromosomes 15 and 17. Also called APL and promyelocytic leukemia.

Is arsenic chemo?

Arsenic trioxide is a chemotherapy drug and is also called Trisenox or ATO. It is a treatment for a type of acute myeloid leukaemia called acute promyelocytic leukaemia (APL).

Is ATRA and tretinoin the same?

Tretinoin is also called all trans retinoic acid (ATRA) and its brand name is Vesanoid. It belongs to a group of drugs called retinoids, these are similar to vitamin A.

What is ATO and ATRA?

ATRA and ATO therapy is a combination treatment of all- trans retinoic acid (ATRA) and arsenic trioxide (ATO) which is now recognised as the first-line treatment for acute promyelocytic leukaemia (APL). A first-line treatment is accepted as the best initial treatment for a given type and stage of a disease.

Is Ato a chemotherapy?

What do promyelocytes become?

A promyelocyte is a type of myeloid cell that normally matures to granulocytes. Eosinophils, neutrophils, and basophils are the three types of mature granulocytes.

How many mg of ATRA should I take for APL?

REFERENCES Studies that have investigated the treatment of APL in adults have mostly used ATRA at a total per-day dose of 45 mg/m 2, usually administered in two divided doses. A lower dose of ATRA, 25 mg/m 2, has been used in the pediatric population.

How much tretinoin (atra) should I take per day?

not present Day / Week Treatment Day 1 up to Day 60 Tretinoin (ATRA) 45mg/m²/day PO in 2 equ Week 1 Days 1-5 ARSENIC TRIOXIDE 0.3mg/kg in 100mL 0.9% Weeks 2–8 2 x / week ARSENIC TRIOXIDE 0.25mg/kg in 100mL 0.9%

Can atra be given by mouth?

Note: If a drug has been approved for one use, physicians sometimes elect to use this same drug for other problems if they believe it might be helpful. ATRA is given by mouth (in capsule form). One size capsule – 10mg, do not crush chew or dissolve capsules.

What is the duration of ATRA therapy?

ATRA is taken for two consecutive weeks followed by two consecutive weeks off where ATRA is not taken, this is known as one Cycle. During consolidation, a total of seven ATRA cycles are taken. Duration of ATRA therapy may last up to seven months, depending upon response, tolerability, and number of cycles prescribed.