What does soluble epoxide hydrolase do?

Soluble epoxide hydrolases (sEH), enzymes present in all living organisms, metabolize epoxy fatty acids (EpFAs) to corresponding 1,2-diols by the addition of a molecule of water. Accumulating evidence suggests that sEH in the metabolism of polyunsaturated fatty acids (PUFAs) plays a key role in inflammation.

What is epoxide hydrolysis?

Basic Hydrolysis The epoxide oxygen forms an alkoxide which is subsequently protonated by water forming the 1,2-diol product. If the epoxide is asymmetric the incoming hydroxide nucleophile will preferable attack the less substituted epoxide carbon.

What is epoxide explain their synthesis and orientation?

An epoxide is a cyclic ether with a three-atom ring. This ring approximates an equilateral triangle, which makes it strained, and hence highly reactive, more so than other ethers. They are produced on a large scale for many applications.

How do you make an epoxide from an alkene?

Treating an alkene with a “peroxyacid” (that’s a carboxylic acid containing an extra oxygen) leads to direct formation of an epoxide. A popular peroxyacid for this purpose is m-CPBA [m-chloroperoxybenzoic acid], although other peroxyacids of the general form RCO3H also find use.

What does EETs mean?

‘Eets’: “Short for Sweet, meaning awesome, describing something that is preferable happening.” Now, you may think you know ‘Peak’ but be wary of the multiple definitions: “It can refer to an excellent or top quality situation/object/event/person. Curiously, it can also refer to a very negative situation.”

What are Epoxyeicosatrienoic acids and where are they generated?

Abstract. Epoxyeicosatrienoic acids (EETs) are cytochrome P450 metabolites of arachidonic acid that are produced by the vascular endothelium in responses to various stimuli such as the agonists acetylcholine (ACH) or bradykinin or by shear stress which activates phospholipase A2 to release arachidonic acid.