What if apolipoprotein is low?

Low levels of apoB. If your test results show that you have lower than normal lipoproteins in your blood, there may be some underlying condition that prevents your body from producing lipoproteins or apolipoproteins. These include: Reye syndrome. Overactive thyroid.

What causes HDL deficiency?

Causes. Mutations in the ABCA1 gene or the APOA1 gene cause familial HDL deficiency. The proteins produced from these genes work together to remove cholesterol and phospholipids from cells.

What if apolipoprotein A1 is low?

A low Apo-A1 level indicates an increased risk of cardiovascular disease, especially in the presence of an elevated apolipoprotein B (Apo-B) level. Other factors that are associated with low Apo A1 level include the following: Chronic liver disease. Chronic kidney disease.

What happens if LDL is high?

If you have a high LDL level, this means that you have too much LDL cholesterol in your blood. This extra LDL, along with other substances, forms plaque. The plaque builds up in your arteries; this is a condition called atherosclerosis.

Why lipoprotein A is high?

High levels of Lp(a) can create plaque in your blood vessels. This is a buildup of cholesterol that lessens blood flow through your arteries. A high level of Lp(a) can be a sign of cholesterol-related disease, such as coronary artery disease. Research has found it to be an independent risk factor for heart disease.

Is a1 High apolipoprotein good?

High levels of apo A-I is considered protective and can be independent of HDL levels. There are some genetic disorders that lead to deficiencies in apo A-I (and therefore to low levels of HDL).

How do you reduce ApoB?

How To Lower ApoBs. Consuming less dietary fat and cholesterol and many more fiber-rich, whole plant foods, which is essentially the Pritikin Eating Plan, will greatly reduce the amount of chylomicrons and their atherogenic, apoB-48-containing lipoproteins in the blood.

What does a low apo A1 mean?

Low levels of apo A-1 are indicative of low levels of HDL and indicate an increased risk of cardiovascular disease. It also indicates inefficient clearance of excess cholesterol from the body. Low levels of apo A-1 and high concentrations of apo B are associated with high risks of cardiovascular disease.

What is the APOA1 gene?

From Genetics Home Reference. Learn more The APOA1 gene provides instructions for making a protein called apolipoprotein A-I (apoA-I). ApoA-I is a component of high-density lipoprotein (HDL). HDL is a molecule that transports cholesterol and certain fats called phospholipids through the bloodstream from the body’s tissues to the liver.

What is the pathophysiology of Apo A-I deficiency?

Preliminary results are consistent with an increase in plasma CET activity in a homozygous subject. Complete apo A-I deficiency appeared to be associated with abnormalities in chylomicron metabolism, which we speculate is due to impaired apo E–dependent clearance.

What is the relationship between apo A1 and apo B?

Low levels of apo A-1 and high concentrations of apo B are associated with high risks of cardiovascular disease. Levels of apo A1 are observed to be decreased in conditions such as: