What is a myoepithelial marker?

Increased basal membrane cells, myoepithelial cells under stress. Laminin-1 is a hormone released in the growth of basal membrane cells, and it’s presence in normal amounts has been traditionally seen as a marker for the absence of invasive breast cancer.

Is p40 a myoepithelial marker?

Sarda R, Taylor J: p40 (ΔNp63), a lung squamous cell marker, can also be used to label breast myoepithelial cells. Arch Pathol Lab Med 2014;138:584.

What is myoepithelial differentiation?

Myoepithelial cells produce and are in direct contact with the basement membrane (BM). Together, these cells outline the inner luminal epithelial cells in both ducts and alveoli, serving as a structural barrier, and they regulate luminal epithelial cell differentiation and polarity1,2,3.

Where is myoepithelial cells?

Myoepithelial cells (MCs) are modified epithelial cells found in sweat, mammary, salivary, lacrimal, and tracheobronchial glands.

What is a metaplastic carcinoma?

Abstract. Metaplastic breast cancer (MpBC) is an exceedingly rare breast cancer variant that is therapeutically challenging and aggressive. MpBC is defined by the histological presence of at least two cellular types, typically epithelial and mesenchymal components.

What is p40 negative?

Based on a literature review, a case with negative p40 is less likely to be squamous cell carcinoma. A study by Tacha et al. [12] described six cases of poorly differentiated lung squamous cell carcinoma (5.6%) that were negative for p40; subsequent staining with other squamous markers were also negative.

Does Oxytocin causes myoepithelial cell contraction?

Oxytocin causes milk ejection by the mammary gland by eliciting contraction of myoepithelial cells, which surround the epithelial cells of the alveoli and the finer ducts (18).

Which glands have myoepithelial cells?

What is the journal’s impact if of Optics Express?

The highest Journal’s Impact IF of Optics Express is 3.894. The lowest Journal’s Impact IF of Optics Express is 3.148. The total growth rate of Optics Express IF is 8.6%. The annual growth rate of Optics Express IF is 0.9%. Optics Express Journal’s Impact IF Prediction System is now online.

What is the ranking of Optics Express?

Optics Express has been ranked #28 over 192 related journals in the Atomic and Molecular Physics, and Optics research category. The ranking percentile of Optics Express is around 85% in the field of Atomic and Molecular Physics, and Optics. The 2021-2022 Journal’s Impact IF of Optics Express is 3.894, which is just updated in 2022.

Does myoepithelial cell expression vary between DCIS-involved ducts?

Myoepithelial cell expression of a-SMA, CALP, and p63 vary between individual DCIS-involved ducts from the same case (Q). Statistical significance was determined by mixed effects analysis of variance and P value justification for multiple comparisons using Tukey-Kramer approach. ****P < 0.0001.

Are myoepithelial nuclei positive for p63 In p63 positive cells?

Myoepithelial nuclei were defined as small nuclei in cells positive for a-SMA and/or calponin on triple immunofluores- cence stained slides (Supplemental Figure S1). These nuclear count data were compared with the visual assessments for scoring the percentage of myoepithelial nuclei positive for p63.