What is a piperazine ring?

Piperazine is a medication used to treat roundworm and pinworm. Generic Name Piperazine DrugBank Accession Number DB00592 Background. Piperazine is an organic compound that consists of a six-membered ring containing two opposing nitrogen atoms.

What is a piperazine ring?

Piperazine is a medication used to treat roundworm and pinworm. Generic Name Piperazine DrugBank Accession Number DB00592 Background. Piperazine is an organic compound that consists of a six-membered ring containing two opposing nitrogen atoms.

Which drug contain piperazine ring?

Piperazine is a very popular motif in CNS drugs as shown in three atypical antipsychotics, one antidepressant, and one sedative hypnotic. Piperazine is also embedded in two tyrosine kinase inhibitors: imatinib (Gleevecâ„¢) and dasatinib (Sprycelâ„¢).

What is piperazine citrate used for?

Anthelmintics are used in the treatment of worm infections. Piperazine is used to treat: common roundworms (ascariasis) and. pinworms (enterobiasis; oxyuriasis).

How do you use piperazine?

For patients taking the granules for oral solution form of piperazine:

  1. Dissolve the contents of 1 packet of granules in 57 mL (about 2 ounces) of water, milk, or fruit juice.
  2. Be sure to drink all of the liquid to get the full dose of medicine.

What is piperazine made of?

Piperazine is an azacycloalkane that consists of a six-membered ring containing two nitrogen atoms at opposite positions. It has a role as an anthelminthic drug. It is a saturated organic heteromonocyclic parent, an azacycloalkane and a member of piperazines. It is a conjugate base of a piperazinium(2+).

Is an example of piperazine derivative?

The piperazine derivatives include 1-benzylpiperazine (BZP), 1,3-trifluoromethylphenylpiperazine (TFMPP), 1-(3-chlorophenyl) piperazine (mCPP) and 1-(4-methoxyphenyl) piperazine (MeOPP); a full summary of their chemical properties is presented in the ‘Physical Descriptions’ section.

What class of drug is piperazine?

Organic compoundPiperazine / Classification

Is piperazine safe in pregnancy?

Given at a dose of 11 mg/kg PO (maximum dose of 1 g/day) 2. Considered safe for use in pregnant women.

What are the side effects of piperazine?

Side Effects

  • Blurring of vision.
  • clumsiness.
  • crawling or tingling feeling of the skin.
  • irregular, twisting movement, especially of the face, arms, and legs.
  • joint pain.
  • skin rash or itching.

What is the side effect of piperazine?

Side-effects include gastrointestinal disturbances, headache, dizziness and urticaria. Seizures occur rarely, and piperazine is contraindicated in patients who have a history of a seizure disorder. Piperazine and pyrantel pamoate are antagonistic and should not be co-administered.

What is piperazine hexahydrate?

Description. An anti-nematodal agent effective against the intestinal nematodes ASCARIS LUMBRICOIDES (roundworm) and ENTEROBIUS VERMICULARIS (pinworm, threadworm). It produces a neuromuscular block leading to flaccid muscle paralysis in susceptible worms, which are then dislodged from the gut and expelled in feces.

What is the structure of a piperazine ring?

Piperazine is an azacycloalkane that consists of a six-membered ring containing two nitrogen atoms at opposite positions. It has a role as an anthelminthic drug. It is a saturated organic heteromonocyclic parent, an azacycloalkane and a member of piperazines.

What is piperazine (piperazine)?

Laboratory Chemical Safety Summary (LCSS) Piperazine is a cyclic organic compound possessing two nitrogen atoms in opposite positions within a 6-member heterocyclic ring that serves as a backbone for piperazine derivatives and acts as a gamma-amino-butyric acid (GABA) receptor agonist in nematodes, with potential anti-helminthic activity.

How many milligrams of piperazine are in a suspension?

Piperazine suspension. Specifications. Each milliliter of suspension contains piperazine monohydrochloride equivalent to 33.5 milligrams (mg) piperazine base. Conditions of use in dogs- (1) Indications for use.

How is piperazine exposed to the general population?

Occupational exposure to piperazine may occur through inhalation and dermal contact with this compound at workplaces where piperazine is produced or used (SRC). Monitoring data indicate that the general population may be exposed to piperazine via inhalation of ambient air (SRC).