What is increased platelet aggregation?

Platelet aggregation and dysfunction is a severe characteristic of cardiovascular disease. In the human body, platelets function to regulate vascular tone [6]. Increased platelet aggregation and reactivity increases the risk of arterial thrombosis and other cardiovascular diseases [6].

What does it mean to decrease platelet aggregation?

Decreased platelet aggregation may be due to: Autoimmune disorders that produce antibodies against platelets. Fibrin degradation products. Inherited platelet function defects.

Is platelet aggregation irreversible?

With a strong stimulus, thrombospondin is released from the platelet a-granules. By interacting with fibrinogen, thrombospondin serves to stabilize the platelet aggregates, which leads to a secondary irreversible phase of aggregation. Platelet aggregation is a crucial step in normal hemostasis.

How do you isolate platelets?

The most common technique for isolating platelets involves centrifugation. Although gentler methods have been devised to isolate platelets by density gradient centrifugation or electrophoresis, these techniques either result in a relatively dilute platelet preparation or are time-consuming.

What causes abnormal platelet aggregation?

genetic disorders (including Bernard-Soulier syndrome, Von Willebrand disease, Glanzmann’s thrombasthenia, or platelet storage pool disease) medication side effects (that affect platelet function) myeloproliferative disorders (such as certain types of leukemia) uremia (a condition caused by significant kidney disease)

What are apheresis platelets?

Platelet reduction apheresis, also known as therapeutic thrombocytapheresis or plateletpheresis, is a nonsurgical therapy that reduces the quantity of platelets in a patient’s blood. Platelets (thrombocytes) are a component of the blood that are important for blood clotting.