What is olanzapine mechanism of action?

Mechanism of Action Olanzapine is an atypical (second-generation) antipsychotic that exerts its action primarily on dopamine and serotonin receptors. It works on dopamine D2 receptors in the mesolimbic pathway as an antagonist, blocking dopamine from potential action at the post-synaptic receptor.

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Does digoxin have a short half life?

Digoxin is absorbed quickly from the gastrointestinal tract with a bioavailability of between 75% and 95%. It is eliminated primarily through kidneys; therefore, it has a half-life of 36-48 hours in patients who have normal kidney function and 3.5-5 days in patients who are anuric.

What is the mechanism of action of aripiprazole?

Aripiprazole functions as a partial agonist at the dopamine D2 and the serotonin 5-HT1A receptors, and as an antagonist at serotonin 5-HT2A receptor. The mechanism of action of aripiprazole, as with other drugs having efficacy in schizophrenia and bipolar disorder, is unknown.

What drugs should not be taken with olanzapine?

Serious Interactions

ANTIPSYCHOTICS; PHENOTHIAZINES/OPIOIDS (COUGH AND COLD)
AGENTS THAT MAY CAUSE RESPIRATORY DEPRESSION/SODIUM OXYBATE.
SELECTED ANTIPSYCHOTICS/SELECTED DOPAMINE AGONISTS.
ANTIPSYCHOTICS; PHENOTHIAZINES; RIVASTIGMINE/METOCLOPRAMIDE.
SELECTED DOPAMINE BLOCKERS/CABERGOLINE.

What is the onset of action of olanzapine?

ZYPREXA IntraMuscular results in rapid absorption with peak plasma concentrations occurring within 15 to 45 minutes.

What is the difference between mechanism of action and mode of action?

A mode of action (MoA) describes a functional or anatomical change, resulting from the exposure of a living organism to a substance. Some sources consider the mode of action to be only at the cellular level. In comparison, a mechanism of action (MOA) describes such changes at the molecular level.

Why does digoxin shorten QT interval?

The ECG features of digoxin effect are seen with therapeutic doses of digoxin and are due to: Shortening of the atrial and ventricular refractory periods — producing a short QT interval with secondary repolarisation abnormalities affecting the ST segments, T waves and U waves.

Why is digoxin given for 5 days?

The half-life of digoxin in an individual with normal renal function is about 1.5 days, and this is increased to about 5 days in patients who are anuric. Because of the significant tissue binding of digoxin it is not removed by dialysis, plasma exchange or exchange transfusions, or during cardiopulmonary bypass.

What receptors does aripiprazole work?

Aripiprazole is a partial agonist at D2 receptors. It may act as an antipsychotic by: Lowering dopaminergic neurotransmission in the mesolimbic pathway.

What is the difference between olanzapine and Abilify?

Zyprexa (olanzapine) is good for treating psychosis, mania, and agitation, but it’s more likely to cause weight gain and sleepiness than other antipsychotics. Helps control your thoughts and mood. Abilify (aripiprazole) is good for treating psychosis and mania, and can help with depression.

What are the most common side effects of olanzapine?

Common side effects may include:

weight gain (more likely in teenagers), increased appetite;
headache, dizziness, drowsiness, feeling tired or restless;
problems with speech or memory;
tremors or shaking, numbness or tingly feeling;
changes in personality;
dry mouth, or increased salivation;

What is the pharmacokinetics of digoxin?

Clinical pharmacokinetics of digoxin About 70 to 80% of an oral dose of digoxin is absorbed, mainly in the proximal part of the small intestine. The degree of binding to serum albumin is 20 to 30%. Digoxin is extensively distributed in the tissues, as reflected by the large volume of distribution. High concentrations are found in the h …

Does quinidine interact with digoxin to increase plasma concentration?

Several recent reports have shown that plasma concentrations of digoxin increase when quinidine is administered along with digoxin; the present study was designed to explore the pharmacokinetics of this digoxin-quinidine interaction in six subjects.

Is digoxin an inotropic or chronotropic agent?

By its positive inotropic effect, digoxin increases the cardiac muscular force of contraction. At the same time, digoxin has a negative chronotropic effect that decreases heart rate by its influence on the cardiac electrical conduction pathway.

What is digoxin used for?

Digoxin is used in several cardiac pathologies such as atrial fibrillation and heart failure. By its positive inotropic effect, digoxin increases the cardiac muscular force of contraction. At the same time, digoxin has a negative chronotropic effect that decreases heart rate by its influence on the cardiac electrical conduction pathway.