What is the cellular basis of breast cancer?
If a cell has a mutated tumor suppressor gene, then the cell can turn into cancer. Cancers can be caused by gene changes that turn on oncogenes or turn off tumor suppressor genes. Changes in many different genes are usually needed to cause breast cancer.
What does it mean to have cancer on a cellular level?
Cancer is a cell growth disease where cells undergo division many more times than normal. This makes the cells prone to replication errors—mistakes that occur during the copying of the DNA on the chromosomes that occurs in each cell division. If these mistakes or mutations are not repaired they accumulate.
What are the main classifications of breast cancer?
Types of Breast Cancer
- Ductal carcinoma in situ (DCIS)
- Invasive breast cancer (ILC or IDC)
- Triple-negative breast cancer.
- Inflammatory breast cancer.
- Paget disease of the breast.
- Angiosarcoma.
- Phyllodes tumor.
What are the 4 major classification of cancer?
The major types of cancer are carcinoma, sarcoma, melanoma, lymphoma, and leukemia.
How does lymphatic system spread the breast cancer?
But the breast’s lymphatic system can also spread diseases such as cancer through the body. Lymphatic vessels provide a highway along which invasive cancerous cells move to other parts of the body. The process is called metastasis. It can lead to the formation of a secondary cancer mass in another part of the body.
How Can cancer be treated at the cellular level?
Radiation therapy is a type of cancer treatment that uses high doses of radiation to kill cancer cells and shrink tumors.
How is a cancerous is different from normal cell?
How is a cancerous cell different from a normal cell?…
| Cancer cells | Normal cells |
|---|---|
| i. Divide in an uncontrolled manner. | i. Divide in a regulated manner. |
| ii. Do not show contact inhibition. | ii. Show contact inhibition. |
What is luminal A and B breast cancer?
This group includes tumors that are ER positive and PR positive, but negative for HER2. Luminal A breast cancers are likely to benefit from hormone therapy and may also benefit from chemotherapy. Group 2 (luminal B). This type includes tumors that are ER positive, PR negative and HER2 positive.
What type of cancer is not curable?
Chronic cancer is cancer that cannot be cured but that ongoing treatment, also called extended treatment, can control for months or years.
What is the molecular classification of breast cancer?
Molecular Classification of Breast Cancer ER + 80% Luminal A Luminal B ER – 20% HER2 Basal Claudin-low …… Molecular Classification of Breast Cancer ER/PR HER2 PCad CK5 EGFR CK14 F G K P Q R S L A B C D E H I J M N O T U V X Z Luminal A Luminal B Sobre – expressão de HER2 Basal IHC TRANSLATION OF MOLECULAR CLASSIFICATION Luminal A
How is breast cancer classified according to the ER status?
According to the status of ER, PR, HER2, breast cancer is classified as luminal A, luminal B, HER2 positive, and triple negative, where triple negative tumors can be further differentiated into at least basal, claudin-low, MBC (metaplastic breast cancer) and interferon-rich.
How many types of breast cancer are there?
Take triple negative breast cancer as an example, it encompasses at least four subtypes, i.e., core basal, claudin-low, metaplastic breast cancer, and interferon-rich, each with distinct molecular features and clinical associations. However, we only have triple negative A and B cell lines.
How many breast cancer cell lines are there?
By analyzing the molecular features of 92 breast cancer cell lines as documented by different literatures, we categorize 84 cell lines into 5 groups to be consistent with breast tumor classification.