What is the pathology of basal cell carcinoma?

The key feature of basal cell carcinoma at low power magnification is of a basaloid epithelial tumour arising from the epidermis (figure 1). The basaloid epithelium typically forms a palisade with a cleft forming from the adjacent tumour stroma (figure 2).

What is the morphology of basal cell tumor?

Infiltrative growth BCC: clinical morphology. The infiltrative growth BCC has a scaly surface, a pink to reddish color and an irregular, ill-defined margin. This is a plaque lesion which can be either slightly elevated or depressed with palpable induration at the tissue edges.

What is granular cell tumor?

Listen to pronunciation. (GRAN-yoo-lur sel TOO-mer) A rare type of soft tissue tumor that usually begins in Schwann cells (cells that hold nerve cells in place). It can occur anywhere in the body, but it usually occurs in or under the skin of the head and neck (especially the mouth or tongue).

What is the major cause of basal cell carcinoma?

Most basal cell and squamous cell skin cancers are caused by repeated and unprotected skin exposure to ultraviolet (UV) rays from sunlight, as well as from man-made sources such as tanning beds.

How common are granular cell tumors?

Background: Granular cell tumors (GCTs) or Abrikossoff’s tumors are rare neoplasms known to originate from Schwann cells in the peripheral nervous system. These lesions are usually benign; malignancy only occurs in 1–2% of cases.

What is the pathology of squamous cell carcinoma?

Squamous cell carcinoma, the second most common form of skin cancer, is caused by the cumulative exposure of skin to UV light. This condition has precursor lesions called actinic keratosis, exhibits tumor progression and has the potential to metastasize in the body.

Is squamous cell carcinoma benign or malignant?

The vast majority of skin cancers are basal cell carcinomas and squamous cell carcinomas. While malignant, these are unlikely to spread to other parts of the body if treated early. They may be locally disfiguring if not treated early. A small but significant number of skin cancers are malignant melanomas.

What is the pathophysiology of basal cell carcinoma (BCC)?

Pathophysiology. Basal cell carcinoma may also manifest as an erythematous patch, papule, nodule or plaque, which is often eroded, ulcerated or indurated Usually only local growth; may be locally destructive with significant morbidity depending on location and size.

Which histologic findings are characteristic of soft tissue tumors (soft tumors)?

Soft tissue tumor with neuroectodermal differentiation composed of large cells with eosinophilic, granular cytoplasm Histology: large cells with eosinophilic, granular cytoplasm; may show pseudoepitheliomatous hyperplasia

What are the signs and symptoms of basal cell carcinoma?

Basal cell carcinoma may also manifest as an erythematous patch, papule, nodule or plaque, which is often eroded, ulcerated or indurated. Usually only local growth; may be locally destructive with significant morbidity depending on location and size.

What do tumor complexes show differentiation?

Tumor complexes can show differentiation towards sebaceous, follicular, eccrine or apocrine structures Tumor cells show differentiation towards matricial cells of the hair follicle displaying shadow cells and trichohyaline granules If playback doesn’t begin shortly, try restarting your device.