What is an inhibin B test for?

What is being tested? Inhibin B is a hormone associated with reproduction and the development of eggs in women and sperm in men. This test measures the inhibin B level in the blood and may be used as part of an infertility evaluation. Inhibin B is made mostly by the ovaries in females, and by the testicles in males.

What is a good inhibin B level?

The normal range of inhibin in post-menopausal women is < 5 pg ml-1, in pre-menopausal women 2-80 pg ml-1 (2-10 pg ml-1 in the follicular phase, 40-80 pg ml-1 in the luteal phase).

What does inhibin B do in males?

Inhibin B is a member of the transforming growth factor beta family of growth factors, and in males is secreted by the Sertoli cells of the testis that are located on the basement membrane of the seminiferous tubules, and nurture and support spermatogenesis.

What is normal inhibin B level in males?

Serum inhibin B level was determined by ELISA. Results: Serum inhibin B level > or = 80 pg/ml was regarded as a normal response.

What does inhibin B do in females?

The main function of inhibin in women is regulation of pituitary FSH secretion. One study showed that a decrease in serum inhibin concentrations could be observed when the ovarian follicular reservoir begins to diminish.

What does inhibin do in females?

inhibin, hormone secreted by the granulosa cells in the ovaries of women that acts primarily to inhibit the secretion of follicle-stimulating hormone by the anterior pituitary gland.

What is the main role of the hormone inhibin in males?

Abstract. Inhibin is a protein secreted by the Sertoli cells in men and by the granulosa cells in women. It inhibits the synthesis and release of the follicle-stimulating hormone in the pituitary gland and reduces the hypothalamic LH – releasing hormone content.

How do you increase inhibin B?

Conclusions: Varicocele treatment can increase serum inhibin B levels, indicating improvement of spermatogenesis and Sertoli cell function. This finding suggests that the pathophysiology of varicocele involves impairment of Sertoli cell function or a different distribution of germ cell stages.

What does high inhibin B mean in men?

Serum inhibin B levels are strongly positively correlated with testicular volume and sperm counts. In infertile patients, inhibin B decreases and FSH increases. In general, there is very good correlation with the degree of spermatogenetic damage, with the arrest at the earlier stages having the lowest inhibin B levels.

What does low inhibin B mean?

79. The measurement may be useful in assessing reproductive aging because a low level of inhibin B on day 3 may indicate a declining ovarian reserve. 78. In men, inhibin B is produced by Sertoli cells and has been considered a good marker of spermatogenesis.

Does inhibin B affect LH?

Serum levels of inhibin B reached a peak at stage G3 of puberty. Around midpuberty, inhibin B lost its positive correlation with luteinizing hormone (LH) and testosterone from early puberty, and developed a strong negative correlation with FSH, which persisted into adulthood.