Does thalassemia cause coagulation?

Affected individuals also have a shortage of red blood cells (anemia ), which can cause pale skin, weakness, fatigue, and more serious complications. People with beta thalassemia are at an increased risk of developing abnormal blood clots.

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Why does thalassemia cause thrombosis?

Thalassemia, an inherited hemolytic disorder, is associated with a high incidence of thrombosis. The major mechanisms underlying thromboembolism (TE) are an abnormal red blood cell surface, platelet activation and endothelial cell activation.

What happens if you have thalassemia trait?

People who have thalassemia trait (also called thalassemia minor) carry the genetic trait for thalassemia but do not usually experience any health problems except perhaps a mild anemia. A person may have either alpha thalassemia trait or beta thalassemia trait, depending upon which form of beta protein is lacking.

Does thalassemia cause Hypercoagulation?

The hypercoagulable state in thalassemia. Thalassemia is associated with partial or complete deficiency of α- or β-globin chain synthesis, which leads to denaturation and degradation of the remaining globin chains.

Does thalassemia increase risk of DVT?

People with thalassemia are at increased risk of thrombosis. Thrombotic events include pulmonary embolism, arterial occlusion, portal thrombosis, and deep vein thrombosis. Approximately 1 to 2 percent of thalassemia major patients and 5 percent of thalassemia intermedia patients experience a serious thrombosis.

What is beta thalassemia trait?

Beta thalassemia is an inherited blood disorder in which the body doesn’t make as much beta globin as it should. Beta globin and alpha globin are building blocks of hemoglobin. Hemoglobin is the part of red blood cell (RBC) that carries oxygen throughout the body.

Does thalassemia cause stroke?

Treating Thalassemia One of the most common and serious complications is stroke. Recent brain MRI studies suggest that thalassemia patients (particularly those with thalassemia intermedia) are at high risk for subclinical infarction or silent stroke.

What causes Hypercoagulability in patients with thalassemia?

The presence of a higher than normal incidence of thromboembolic events, mainly in β-TI, and the existence of prothrombotic hemostatic anomalies in the majority of the patients, even from a very young age, have led to the recognition of the existence of a chronic hypercoagulable state in thalassemic patients.

What is the pathophysiology of thalassemia?

Thalassemia is a congenital hemolytic disorder caused by a partial or complete deficiency of α- or β-globin chain synthesis. Homozygous carriers of β-globin gene defects suffer from severe anemia and other serious complications from early childhood.

Is beta-thalassemia intermedia a hypercoagulable state?

The presence of a high incidence of thromboembolic events, mainly in beta-thalassemia intermedia, has led to the identification of a hypercoagulable state in these patients.

How is thalassemia treated?