How does granulocyte colony-stimulating factor G-CSF work?

Granulocyte colony-stimulating factor (G-CSF) is a blood growth factor (special proteins produced by the body) that stimulates the bone marrow to produce more infection-fighting white blood cells called neutrophils. Granulocyte colony-stimulating factor causes cells from the bone marrow to become mature and activated.

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Does G-CSF increase neutrophils?

During the course of an infection, serum levels of G-CSF increase which in turn enhances proliferation of granulocytic precursor cells and an increased level of circulating neutrophils (23).

What is recombinant G-CSF?

Recombinant Human G-CSF is purified E. coli expressed recombinant human granulocyte colony stimulating factor (G-CSF). Granulocyte CSF is produced by monocytes and fibroblasts. It stimulates granulocyte colony formation, activates neutrophils and differentiates certain myeloid leukemic cells.

What is filgrastim used for?

Filgrastim injection is used to treat neutropenia (low white blood cells) that is caused by cancer medicines. It is a synthetic (man-made) form of a substance that is naturally produced in your body called a colony stimulating factor. Filgrastim helps the bone marrow to make new white blood cells.

What cells produce G-CSF?

Human G-CSF is produced mainly by monocytes and macrophages (2), but is also produced by fibroblasts (3), endothelial cells (4), and bone marrow stromal cells (5).

What is G-CSF neutrophils?

Further, G-CSF influences the function of mature neutrophils. These actions underpin its rapid uptake into clinical medicine as a drug that increases the production of neutrophils in patients with chemotherapy-induced neutropenia. Ongoing research has uncovered initially unsuspected polyfunctionality for G-CSF.

How does a colony-stimulating factors work?

Colony-stimulating factors (CSFs) are secreted glycoproteins that bind to receptor proteins on the surfaces of hematopoietic stem cells, thereby activating intracellular signaling pathways that can cause the cells to proliferate and differentiate into a specific kind of blood cell, usually white blood cells.