How does MTHFR affect folate metabolism?
The MTHFR gene provides instructions for your body to make the MTHFR protein, which helps your body process folate. Your body needs folate to make DNA and modify proteins. A gene variant is a change in a DNA sequence that is different from the expected DNA sequence.
Does MTHFR mutation cause B12 deficiency?
For instance, mutations and polymorphisms in transport proteins such as transcobalamin TCN, gastric intrinsic factor GIF and metabolic enzymes such as methylenetetrahydrofolate reductase MTHFR have been associated with vitamin B12 deficiency.
Should you avoid folic acid if you have MTHFR?
Avoid all products with added or fortified folic acid which is the synthetic form of vitamin B9 found in fortified supplements (pregnancy supplements) breads, cereals and commercially produced flours.
What happens if you have MTHFR and take folic acid?
These people have very low activity of the MTHFR protein in the body. This results into a highly reduced ability of the body to convert folic acid into a usable form and can lead to accumulation of the amino acid homocysteine – which is toxic to the body.
What supplements should you take if you have MTHFR?
It’s important to opt for a supplement that contains the most bioavailable form of folate—methyl-folate—which can help your body absorb the vitamin more efficiently. Additional supplements that help support this genetic variant include magnesium, vitamin D, and vitamin B6.
How much folate should I take for MTHFR?
MTHFR gene polymorphisms [1]. Many Physicians prescribe 4-5mg of folate QD in patients who are trying to, or have conceived. In addition to the prenatal vitamin supplements, synthetic folic acid is combined with many flours and grains we purchase.
How much folate do you need for MTHFR mutation?
What vitamins should you take if you have MTHFR?
Methyl-B12, methyl-folate, TMG, N-acetylcysteine, riboflavin, curcumin, fish oil, Vitamins C, D, E, and probiotics are excellent supplements your body will love more so if you have an MTHFR mutation.
What supplements should I take if I have MTHFR?
What supplements to avoid with MTHFR?
Proponents of the MTHFR diet and lifestyle have suggested that those with MTHFR gene polymorphisms should avoid folic acid supplements (the more common and synthetic form of folate). Instead, they suggest opting for more expensive methyl-folate supplements (also known as 5-methyltetrahydrofolate or 5-mthf).
What is the recommended dosage of B12 per day?
While the recommended daily amount of vitamin B-12 for adults is 2.4 micrograms, higher doses have been found to be safe. Your body absorbs only as much as it needs, and any excess passes through your urine.
What could be causing abnormal vitamin B12 levels?
What could be causing abnormal vitamin B12 levels? Elevated levels of B12 are rare and often caused by disease, most commonly decreased liver function or diseases of the blood. Elevated levels of B12 can be caused by cirrhosis, scarring of the liver.
What are the signs of a B12 deficiency?
Muscle cramps and muscle weakness. B12 deficiency negatively impacts motor and sensory nerve function,which can cause muscle cramps and weakness ( 7,27 ).
How much Vit B12 should you take for hypothyroidism?
I generally recommend sublingual 1000mcg of Vit. B12 daily. Here’s the Vitamin B12 Supplement I suggest to my patients for Thyroid. The injectable will have different dosages generally around 1000 mcg once a week initially for 1 month and then 1000mcg once a month.