How long can you live with splenic marginal zone lymphoma?

Splenic marginal zone lymphoma (SMZL) is a rare, indolent non-Hodgkin’s lymphoma that affects 0. 13 per 100,000 persons annually. Overall survival of SMZL is estimated to reach 8–11 years in most cases, but up to 30% of SMZL cases develop aggressive presentations resulting in greatly diminished time of survival.

Is splenic marginal zone lymphoma rare?

Splenic marginal zone lymphoma (splenic MZL) is rare. It accounts for fewer than 2 in every 100 cases of non-Hodgkin lymphoma. Splenic MZL can affect people of any age but it is most common in people in their 60s.

Is marginal zone lymphoma fatal?

Five-year survival rates are reported as follows: 88.7 percent for MALT, 79.7 percent for splenic MZL, 76.5 percent for nodal MZL. Though the majority of SMZL run an indolent course similar to EMZL, overall, SMZL has poorer outcomes due to a relatively larger proportion of patients who present with aggressive disease.

What causes splenic marginal zone lymphoma?

The causes of splenic marginal zone lymphoma (SMZL) are mostly unknown. It is sometimes linked to long-term infection with the hepatitis C virus (HCV). But it is important to remember that most people with HCV will not develop lymphoma. SMZL can affect people of all ages, but is most common in people over 70.

What stage is lymphoma in the spleen?

Stage I lymphoma In stage I non-Hodgkin and Hodgkin lymphoma, cancer is found in one lymphatic area — the lymph nodes, tonsils, thymus, spleen, or one localized non-lymph site.

Can marginal zone lymphoma be cured?

Most patients with nodal marginal zone lymphoma present with advanced stage disease and are not likely to achieve cure, even with aggressive chemotherapy regimens. Moreover, there is little evidence that choice of initial therapy has any impact on survival.

Is nodal marginal zone lymphoma curable?

Clinical outcome and prognostic factors in NMZL. The clinical outcome of NMZL patients is similar to that of other nodal indolent lymphomas. To date, the disease has not proven curable with classical chemotherapy and is characterized by a continuous pattern of relapses.

How many people have nodal marginal zone lymphoma?

Nodal marginal zone lymphoma (nodal MZL) is rare. It accounts for fewer than 2 in every 100 cases of non-Hodgkin lymphoma. Nodal MZL can affect people of any age but it is most common in people over 50. There is a very rare paediatric variant of nodal MZL that affects children.