Is IgG4 disease a vasculitis?

IgG4-RD is a distinctive, unique, and treatable cause of large-vessel vasculitis. It can also involve blood vessels secondary to perivascular tumefactive lesions. The most common manifestation of IgG4-related vasculitis is aortitis with aneurysm formation.

Is IgG4 an inflammatory disease?

Abstract. IgG4-related disease is a fibro-inflammatory condition that can affect nearly any organ system. Common presentations include major salivary and lacrimal gland enlargement, orbital disease, autoimmune pancreatitis, retroperitoneal fibrosis and tubulointerstitial nephritis.

Is IgG4 life threatening?

IgG4-related periaortitis/periarteritis: An under-recognized condition that is potentially life-threatening. Mod Rheumatol. 2019 Mar;29(2):240-250. doi: 10.1080/14397595.2018.

Is IgG4 an autoimmune disease?

IgG4-RD is a recently recognised, rare autoimmune condition that can affect most organs and links a number of inflammatory diseases that previously were considered unrelated and affecting only one organ.

Is IgG4 curable?

It may also lead to swelling that can be mistaken for tumors. Particularly if diagnosed early, IgG4-RSD is highly treatable.