What are HLA in type 1 diabetes?
Human leukocyte antigen (HLA) class II genes contribute to the genetic susceptibility to type 1 diabetes (T1D), and susceptible alleles and haplotypes were implicated in the pathogenesis of T1D. This study investigated the heterogeneity in HLA class II haplotype distribution among Tunisian patients with T1D.
How does HLA cause type 1 diabetes?
Type 1 diabetes (T1D) is one of the most widely studied complex genetic disorders, and the genes in HLA are reported to account for approximately 40% to 50% of the familial aggregation of T1D. The major genetic determinants of this disease are polymorphisms of class II HLA genes encoding DQ and DR.
Which type of diabetes is influenced by HLA-DRB1?
The HLA class II locus DPB1 can influence susceptibility to type 1 diabetes. Diabetes 2000; 49: 121–125. Cucca F, Dudbridge F, Loddo M et al. The HLA-DPB1–associated component of the IDDM1 and its relationship to the major loci HLA-DQB1, -DQA1, and -DRB1.
How common is HLA-DR4?
A study by Russell et al. [123], reported a frequency of HLA-DR4 antigen of 70% among 20 patients with hydralazine-related lupus compared with a frequency of 33% in the general population. Six of these 20 patients had been included in the 1980 study by Batchelor et al.
What is HLA DR3 DR4?
The class II gene products, HLA-DR3 and DR4, may be the primary susceptibility genes for IDDM. They mediate the pathogenetical immune mechanisms which, under the additional influence of special MHC-genes of class I and III, lead to diabetes.
What is HLA DR3 and DR4?
What is DR3 and DR4?
Which of the following auto immune disease is associated with HLA-DR4?
Table 1
| HLA Class II Effects | AUTOIMMUNE DISEASE | |
|---|---|---|
| Predisposing | Protective | |
| DR4 DR3 | DR7 | Hashimoto’s thyroiditis |
| DR3 | ◊ | Myasthenia Gravis |
| DR3 | ◊ | Addison’s disease |