What causes idiopathic granulomatous mastitis?

What causes idiopathic granulomatous mastitis?

The etiology of idiopathic granulomatous mastitis is still obscure. Its treatment remains controversial. The cause may be the autoimmune process, infection, a chemical reaction associated with oral contraceptive pills, or even lactation.

How do you treat idiopathic granulomatous mastitis?

Steroid therapy, as a therapeutic method such as prednisolone, was an effective and applicable choice in the treatment of idiopathic granulomatous mastitis by decreasing in inflammation. There is no acceptable method of treatment for IGM. We found that high-dose steroid therapy is the choice treatment for IGM.

What is granulomatous mastitis in breast?

Granulomatous mastitis (GM) is a rare chronic inflammatory breast condition that was first described in 1972. 1. Granulomatous changes occur around lobules and ducts of the breast in the absence of specific infection, trauma, or evidence of sarcoidosis.

Is granulomatous mastitis serious?

Granulomatous mastitis (GM) is a rare benign inflammatory breast disease that affects mostly women of childbearing age with a history of breastfeeding.

Can you breastfeed with granulomatous mastitis?

3.2 Treatment methods and results Postpartum breastfeeding was encouraged, especially on the affected side. The healing time of postpartum granuloma is 2 to 18 months. The median healing time (it starts during pregnancy) was 20 months, and the average healing time was 30.4 months in 5 healthy breast lactation cases.

How long does it take for granulomatous mastitis to heal?

Some sources report that approximately half of the patients will fully recover after 2–24 months management. One review recommended complete resection or corticosteroid therapy, stating also that long-term follow-up was indicated due to a high rate of recurrence. Treatment with steroids usually requires about 6 months.

Is granulomatous mastitis an autoimmune disease?

As an autoimmune disease, idiopathic granulomatous mastitis appears to have different manifestations and severity in different patients; therefore, a same treatment cannot be used for all patients with histologically-diagnosed IGM. The disease is self-limited and remitted spontaneously in some patients.

How long does granulomatous mastitis last?

There is often ulceration, abscess and sinus formation. Triple assessment is needed to confirm diagnosis. GM may last for 12 months or more before healing occurs. Options for management are conservative/supportive care, oral prednisone or methotrexate, or surgical excision.

Will granulomatous mastitis go away on its own?

In this study, various treatment methods were applied based on the medical conditions of the patients and on the clinical judgment of the physicians. It has been reported that GLM is a self-limiting condition and can be expected to disappear on its own within 6-12 months with close surveillance [16,17].

What happens if you leave mastitis untreated?

While mastitis is almost never an emergency, left untreated it can lead to a breast abscess, which is a collection of pus in a hollow area in the breast. Your doctor may need to drain the abscess. A wiser course is to never let mastitis lead to an abscess.

What is granulomatous mastitis?

Granulomatous Mastitis: A Therapeutic and Diagnostic Challenge Granulomatous mastitis (GM) is a rare benign inflammatory breast disease that affects mostly women of childbearing age with a history of breastfeeding.

Is clarithromycin an effective treatment for granulomatous mastitis?

• An extended course of a lipophilic antibiotic, such as clarithromycin, that has adequate tissue penetrance within lipid-filled spaces may be an option for treating GM. Introduction Granulomatous mastitis (GM) is a challenging clinical condition first described in 1972 by Kessler and Wolloch (1).

What causes granulomatous mastitis in young women with hyperprolactinemia?

Two cases of granulomatous mastitis caused by corynebacterium kroppenstedtii infection in nulliparous young women with hyperprolactinemia. Intern Med. 2015;54:1815–1818.

Is granuloma pathogenic in the breast?

However, the hypothesis that these organisms can be pathogenic in the breast is gaining momentum (20, 21, 22, 23), and is consistent with what is understood about granuloma formation in other settings.