What does GRHL2 mean?

GRHL2 (Grainyhead Like Transcription Factor 2) is a Protein Coding gene. Diseases associated with GRHL2 include Ectodermal Dysplasia/Short Stature Syndrome and Deafness, Autosomal Dominant 28 .

What is the function of GRHL2 gene in extraocular muscles?

GRHL2 gene may have a role in orbital innervations and the defect in this gene (deletion) may be related to the Congenital fibrosis of the extraocular muscles type 1 phenotype. In this study, we demonstrated for the first time that GRHL2 has a functional role in the regulation of epithelial plasticity of PDAC cells.

How does GRHL2 reduce invasion and migration?

Grhl2 reduces invasion and migration through inhibition of TGFβ-induced EMT in gastric cancer Metastasis is one of the typical features of malignancy that significantly increases cancer-related mortality. Recent studies have shown that epithelial-mesenchymal transition (EMT) is closely related to the invasion and migration of cancer cells.

What is the role of GRHL2 in breast cancer?

Grhl2 plays an essential role in the determination of epithelial phenotype of breast cancers, EMT and tumor progression GRHL2 impairs keratinocyte differentiation through transcriptional inhibition of the genes clustered at the epidermal differentiation complex.