What is a database variant?

A genetic variant database contains information about genetic differences (also called genetic variants). Researchers submit data to these databases, which collect, organize, and publicly document the evidence supporting links between a human genetic variant and a disease or condition.

What is a pLI score?

The pLI score reflects the tolerance of a given gene to the loss of function on the basis of the number of protein truncating variants, that is, the frameshift, splice donor, splice acceptor, and stop-gain variants referenced for this gene in control databases weighted by the size of the gene and the sequencing …

What is dbVar database?

dbVar is a database of human genomic structural variation where users can search, view, and download data from submitted studies. dbVar stopped supporting data from non-human organisms on November 1, 2017; however existing non-human data remains available via FTP download.

What does a pLI score of 1 mean?

Loss-of-function: pLI closer to 1 indicates that the gene or transcript cannot tolerate protein truncating variation (nonsense, splice acceptor and splice donor variation).

What is function intolerance loss?

Loss-of-function (LoF) variants in genes are defined as those which impair or eliminate the function of the encoded protein. Despite their protein-coding disruption, it has been shown that some LoF variants can be tolerated in healthy individuals [1–4].

What data does GWAS use?

Genome-wide association studies (GWAS) use high-throughput genomic technologies to scan entire genomes of large numbers of subjects quickly, in order to find genetic variants correlated with a trait or disease.

What is a variant data type?

A Byte is promoted to an Integer, an Integer is promoted to a Long, and a Long and a Single are promoted to a Double. An error occurs when Variant variables containing Currency, Decimal, and Double values exceed their respective ranges. You can use the Variant data type in place of any data type to work with data in a more flexible way.

What is the range of numeric variant data?

Numeric data can be any integer or real number value ranging from -1.797693134862315E308 to -4.94066E-324 for negative values and from 4.94066E-324 to 1.797693134862315E308 for positive values. Generally, numeric Variant data is maintained in its original data type within the Variant.

How does SQL_variant compare two different base data types?

When sql_variant values of different base data types are compared and the base data types are in the same data type family, the value whose base data type is lower in the hierarchy chart is implicitly converted to the other data type and the comparison is then made.

What is a variant in C++?

A Variant is a special data type that can contain any kind of data except fixed-length String data. ( Variant types now support user-defined types .) A Variant can also contain the special values Empty, Error, Nothing, and Null. You can determine how the data in a Variant is treated by using the VarType function or TypeName function.