What is alhydrogel?

Alhydrogel is a range of aluminium hydroxide gel products which have been specifically developed for use as an adjuvant in human and veterinary vaccines. The gel is a suspension of boehmite-like (aluminium oxyhydroxide) hydrated nano/micron size crystals in loose aggregates.

What CpG 1018?

CpG 1018 is the adjuvant contained in HEPLISAV-B®, the Company’s U.S. FDA-approved hepatitis B vaccine.

Who makes alhydrogel?

Croda
Alhydrogel® adjuvant 2% is made by Croda (following its acquisition of Brenntag Biosector A/S), a leader in the global vaccine adjuvants market with a long history of producing high quality products.

What is aluminum Trihydroxide?

Aluminum hydroxide is an inorganic salt used as an antacid. It is a basic compound that acts by neutralizing hydrochloric acid in gastric secretions.

What is AddaVax medication used for?

AddaVax, a squalene-based oil-in-water (w/o) nano-emulsion, similar to MF59, has been approved as a seasonal influenza vaccine component in Europe for people aged 65 and older(5). AddaVax is used in experimental vaccines to enhance antibody titers (6–8).

What is MF59 vaccine?

MF59 is an immunologic adjuvant that uses squalene. It is Novartis’ proprietary adjuvant that is added to influenza vaccines to help stimulate the human body’s immune response through production of CD4 memory cells.

Is aluminum a vaccine?

Aluminum-containing adjuvants are vaccine ingredients that have been used in vaccines since the 1930s. Small amounts of aluminum are added to help the body build stronger immunity against the germ in the vaccine. Aluminum is one of the most common metals found in nature and is present in air, food, and water.

What is alumina trihydrate used for?

Alumina trihydrate is used commercially as a paper coating, flame retardant, water repellant, and as a filler in glass, ceramics, inks, detergents, cosmetics, and plastics.

What is AddaVax adjuvant?

Vaccine Adjuvant: Squalene-Oil-in-water. AddaVax™ is a squalene-based oil-in-water nano-emulsion with a formulation similar to that of MF59® that has been licensed in Europe for adjuvanted flu vaccines [1]. Squalene is an oil more readily metabolized than the paraffin oil used in Freund’s adjuvants [1].

What vaccines use MF59?

Vaccine Use in Immunocompromised Adults Two oil-in-water adjuvants (AS03 and MF59) have been used in combination with influenza vaccines to boost their immunogenicity. The MF59-adjuvanted influenza vaccine has been FDA approved for those aged ≥65 years.

What is Alhydrogel® adjuvant?

Alhydrogel® adjuvant is an aluminium hydroxide (referred to as alum) wet gel suspension. Alhydrogel® adjuvant 2% is provided as a ready-to-use, aluminium hydroxide wet gel (colloidal) suspension.

How many ml of Alhydrogel 2% is in the sample?

250 ml Alhydrogel 2% is provided as a ready-to-use, aluminium hydroxide wet gel (colloidal) suspension. Alhydrogel is sterilized by autoclavation and aseptically filled.

What is the CAS number for Alhydrogel?

CAS Number: 21645-51-2 Formulation: Al(OH)3, Aluminium hydroxide gel Appearance: White gelatinous precipitate Aluminium content: 9.0 – 11.0 mg/ml pH: ~6.5 DESCRIPTION Alhydrogel®adjuvant is an aluminium hydroxide (referred to as alum) wet gel suspension.

How should Alhydrogel 2% be stored?

Alhydrogel 2% is shipped at room temperature and should be stored at room temperature. Product is stable for 6 months. DO NOT FREEZE. Note: Do not expose to frost as product will be destroyed if ice crystals form in the gel. Alhydrogel is an aluminium hydroxide (referred to as alum) wet gel suspension.