What is amantadine hydrochloride capsule used for?

Amantadine is used to treat the symptoms of Parkinson’s disease (PD; a disorder of the nervous system that causes difficulties with movement, muscle control, and balance) and other similar conditions.

What is the generic name of amantadine?

SYMMETREL (Amantadine Hydrochloride, USP) is designated generically as amantadine hydrochloride and chemically as 1-adamantanamine hydrochloride.

What are characteristics of amantadine?

Amantadine is an antiviral drug which also acts as an antiparkinson agent, for which it is usually combined with L-DOPA when L-DOPA responses decline (probably due to tolerance). It is a derivate of adamantane, like a similar drug rimantadine.

Are amantadine tablets and capsules interchangeable?

Note: Amantadine is available as an IR capsule, tablet, and syrup and an ER capsule and tablet. The IR formulations are interchangeable with one another, but they are not interchangeable with the ER formulations; the ER formulations are not interchangeable with one another.

What color is amantadine?

amantadine HCl 100 mg capsule. This medicine is a red blue, oblong, capsule imprinted with “R” and “037”.

What is amantadine side effect?

Blurred vision, nausea, loss of appetite, drowsiness, dizziness, lightheadedness, headache, dry mouth, constipation, or trouble sleeping may occur. If any of these effects last or get worse, tell your doctor or pharmacist promptly. Dizziness and lightheadedness can increase the risk of falling.

Does amantadine affect blood pressure?

Amantadine antagonizes the blood pressure responses evoked by electrical stimulation of the central and peripheral end of the vagus. Blood pressure responses on sympathetic stimulation are also attenuated. These results could be explained on the basis of a possible effect on autonomic ganglia.

How much amantadine can you take in a day?

Adults—129 milligrams (mg) once a day in the morning. Your doctor may increase your dose each week to a maximum dose of 322 mg (one 129 mg tablet and one 193 mg tablet) once a day taken in the morning. Children—Use and dose must be determined by your doctor.

What class of drug is amantadine?

This medication is an antiviral that is believed to work by stopping growth of the flu virus.

What drug is similar to amantadine?

Like amantadine immediate release, Osmolex ER treats Parkinson’s symptoms, such as slowness, stiffness and tremor. (It does not have FDA approval for dyskinesia.) Unlike amantadine immediate release , Osmolex ER is taken once a day, in the morning.

What is amantadine 100mg?

Amantadine is an antidyskinetic medicine. It is used to treat Parkinson’s disease (sometimes called “paralysis agitans” or “shaking palsy”) and its symptoms, including dyskinesia (sudden uncontrolled movements). It may be given alone or in combination with other medicines (eg, levodopa) for Parkinson’s disease.

Is amantadine safe to take?

It has not been confirmed that amantadine is safe and effective for use in people younger than 18 years. The kidneys of older adults may not work as well as they used to. This can cause your body to process drugs more slowly. As a result, an increased amount of a drug stays in your body for a longer time.

What is the USP standard for amantadine hydrochloride?

USP Reference standards 11— USP Amantadine Hydrochloride RS . Clarity and color of solution— Dissolve 2 g in 10 mL of water: the solution is clear and nearly colorless. Solution— Dissolve about 50 mg in 10 mL of 0.1 N hydrochloric acid, and filter.

How do you make amantadine hydrochloride test solution?

Test solution— Transfer about 1.0 g of Amantadine Hydrochloride, accurately weighed, to a separator. Add 20 mL of 5.0 N sodium hydroxide and 18 mL of dichloromethane, and shake for 10 minutes.

What is the mechanism of action of amantadine?

Mechanism of Action: Antiviral. The mechanism by which amantadine exerts its antiviral activity is not clearly understood. It appears to mainly prevent the release of infectious viral nucleic acid into the host cell by interfering with the function of the transmembrane domain of the viral M2 protein.

How long does it take for amantadine to peak?

The time to peak concentration was 3.3 ± 1.5 hours (range: 1.5 to 8.0 hours). 0.28 ± 0.11 L/hr/kg (range: 0.14 to 0.62 L/hr/kg). The half-life was 17 ± 4 hours (range: 10 to 25 hours). Across other studies, amantadine plasma half-life has averaged 16 ± 6 hours (range: 9 to 31 hours) in 19 healthy volunteers.